Persona: Díaz Mardomingo, María del Carmen
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0000-0002-0633-3944
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Díaz Mardomingo
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María del Carmen
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Publicación Sex-related differences in the associations between diurnal cortisol pattern and social and emotional loneliness in older adults(Frontiers Media, 2023) Utrera Martínez, Lucía; Sampedro Piquero, Patricia; Díaz Mardomingo, María del Carmen; Baliyan, Shishir; García Herranz, Sara; Suárez Falcón, Juan Carlos; Rodríguez Fernández, Raquel; Valencia Jiménez, Azucena; Venero Núñez, CésarLoneliness is a distressful feeling that can affect mental and physical health, particularly among older adults. Cortisol, the primary hormone of the Hypothalamic-Pituitary-Adrenal axis (HPA-axis), may act as a biological transducer through which loneliness affects health. While most previous studies have evaluated the association between loneliness, as a unidimensional construct, and diurnal cortisol pattern, no research has examined this relationship discriminating between social and emotional loneliness in older adults. As sex differences in the negative mental health outcomes of loneliness have been reported, we also investigated whether diurnal cortisol indices and loneliness associations occur in a sex-specific manner. We analyzed the diurnal cortisol- pattern in 142 community-dwelling, non-depressed, Caucasian older adults (55,6% female) aged 60-90. Social and emotional (family and romantic) loneliness scores were assessed using the Spanish version of the Social and Emotional Loneliness Scale for Adults (SELSA). Five salivary cortisol samples were used to capture key features of the diurnal cortisol pattern, including: awakening and bedtime cortisol levels, awakening response (CAR), post-awakening cortisol output (post-awakening cortisol [i.e., the area under the curve with reference to the ground: AUCG]), total diurnal cortisol release (AUCG), and diurnal cortisol slope (DCS). After controlling for sociodemographic variables, the hierarchical linear multiple regression analyses revealed that in male older adults, higher scores on social and family loneliness were associated with elevated awakening cortisol levels, total diurnal cortisol output, and a steeper diurnal cortisol slope (DCS). However, these associations were not observed in female older adults. In addition, feelings of romantic loneliness were positively associated with bedtime cortisol levels and AUCG in older males. Multilevel growth curve modeling showed that experiencing more social and emotional loneliness predicted higher diurnal cortisol output throughout the day in older male adults. The presence of sex differences in the relationship between cortisol indices and loneliness among older adults holds particular significance for diagnostic and screening procedures. Combining loneliness scales as screening tools with diurnal cortisol measures has the potential to be an effective and cost-efficient approach in identifying higher-risk individuals at early stagesPublicación Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults(Elsevier, 2023-12) V. Calvo, María; Loria Kohen , Viviana; Díaz Mardomingo, María del Carmen; García Herranz, Sara; Baliyan, Shishir; Carneiro , João Tomé; Colmenarejo, Gonzalo; Visioli, Francesco; Venero Núñez, César; Fontecha, Javier; Elsevier; https://orcid.org/0000-0002-6785-7661; https://orcid.org/0000-0001-8686-3306; https://orcid.org/0000-0002-3597-9234; https://orcid.org/0000-0002-8249-4547; https://orcid.org/0000-0001-5719-2304Cognitive decline is one of the most important consequences of aging and pharmacological therapies had been largely unsuccessful. Other strategies include the use of functional foods to reduce the burden of cognitive decline. The MFGM is an important source of polar lipids and glycoproteins that decline in the aging brain. We have developed a milk drink fortified with MFGM (MFGM-M) as a dietary supplement and studied it in a randomized clinical pilot study. Forty-four > 65-year-old healthy or mildly cognitively impaired subjects received MFGM-M or control milk (CM) for 14 weeks, during which they underwent a battery of cognitive tests. Lipidomic analyzes were also performed. The female participants showed improvement in episodic memory, the ability to recall events in our lives. It is conceivable that any intervention should be started before clinical symptoms manifest, as a preventive measure against cognitive decline. Future long-term studies may shed further light on this pointPublicación Accuracy of verbal fluency tests in the discrimination of mild cognitive impairment and probable Alzheimer's disease in older Spanish monolingual individuals(Taylor and Francis Online, 2019-12-10) García Herranz, Sara; Díaz Mardomingo, María del Carmen; Venero Núñez, César; Peraita Adrados, HerminiaThe main objetive was to analyze the accuracy of different verbal fluency tests (VFTs) in discriminating cognitively healthy subjects from individuals with mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) in a cohort of older Spanish speaking adults. As a result, we aimed to identify the VFT that best predicts conversion from MCI to probable AD. 287 subjects: 170 controls (HC), 90 stable MCI and 27 patients with MCI that evolved into probable AD (MCI-AD) were assessed with a neuropsychological battery test and five VFTs. The animal fluency test produced the best differentiation of HC from MCI (p < .001), of HC from MCI-AD (p < .001) and of MCI from MCI-AD converters (p < .001), with sensitivities 98.8%, 98.8% and 75.6%, respectively. Logistic regression showed that the animal fluency test (p < 0.001) appears to be the most useful and neuropsychological VFT to predict conversion to probable dementia.Publicación Normative data for the for Verbal Fluency, Trail Making and Rey-Osterrieth Complex Figure tests on monolingual Spanish-speaking older adults(Oxford University Press, 2022-01-03) García Herranz, Sara; Díaz Mardomingo, María del Carmen; Suárez Falcón, Juan Carlos; Rodríguez Fernández, Raquel; Peraita, Herminia; Venero Núñez, CésarObjective This study aimed to generate updated normative data for commonly used tests in neuropsychological assessment applied to older monolingual Spanish-speaking adults: Verbal fluency tests, the Trail Making Test (TMT), and the Rey–Osterrieth complex figure test (ROCF). Method To obtain normative data, 382 cognitively healthy 60- to 90-year-old Spanish monolingual participants from the Autonomous Community of Madrid (Spain) with 0–22 years education were assessed using an overlapping interval strategy that involved cell and midpoint techniques, and that assessed the influence of age, education, and sex. Results Age and education were associated with the scores in the verbal fluency tests, TMT, and ROCF, whereas sex only significantly affected the TMT results. Age-adjusted scaled scores (SSA) based on percentile ranks were also converted into age–education scaled scores (SSAE) using a linear regression model. In addition, tables with the relevant adjustments for sex are provided for TMT-A and TMT-B. Conclusions Thus, this study provides updated, uniform normative data for widely used neuropsychological tests on older Spanish adults. The normative procedure followed helps to make consistent comparisons when using these neuropsychological tests, which will improve the interpretation of the data obtained when these tools are employed, reducing the risk of misdiagnosing cognitive impairment in older adults.Publicación Acquisition and consolidation of verbal learning and episodic memory as predictors of the conversion from mild cognitive impairment to probable Alzheimer’s disease(Taylor and Francis Online, 2024-04-22) López-Pérez, Jorge; García Herranz, Sara; Díaz Mardomingo, María del CarmenVerbal episodic memory tests assess memory performance using total learning scores. The analysis of inter-trial indices such as gained (GA) and lost (LA) access can provide additional information on the acquisition and consolidation processes. The main objetive was to determine whether the GA and LA indices, derived from a word-list verbal episodic memory test are useful for predicting cognitive impairment in aging. 60 older people aged was divided into 3 groups: cognitively healthy, stable Mild Cognitive Impairment (MCI) and MCI converting to probable Alzheimer's disease (MCI-conv). The results showed that GA and LA measures are independent from the traditional measures -total score of correct answers-. Logistic regression showed that these values are predictive of the conversion over time and could be a cognitive marker of conversion from MCI to AD. This suggests that the GA index, which shows acquisition processes in word-list tests, may be a marker of cognitive impairment.Publicación Social Loneliness in Older Adults with Mild Cognitive Impairment: Predictive Factors and Associated Clinical Characteristics(SAGE Publications, 2023-12-23) Prada Crespo, David; Montejo Carrasco, Pedro; Díaz Mardomingo, María del Carmen; Villalba Mora, Elena; Montenegro Peña, MercedesAbstract. Background: Loneliness and social isolation are considered public health problems among older individuals. In addition, both increase the risk of developing cognitive impairment and dementia. The Social Loneliness construct has been proposed to refer to these harmful social interaction-related factors. Objective: To define the risk factors of Social Loneliness in individuals with mild cognitive impairment (MCI) and to analyze cognitive, emotional, and functional differences according to the participant’s degree of Social Loneliness. Methods: Through convenience sampling, 105 participants over 60 diagnosed with MCI were selected. The evaluation consisted of anamnesis and a comprehensive neuropsychological examination. The ESTE-II questionnaire was used to assess Social Loneliness and its three factors: perceived social support, social participation, and use of communication technologies. Personality was measured with the NEO-FFI questionnaire. Results: The predictors of the Social Loneliness factors were as follows; 1) perceived social support (R2 = 0.33): Neuroticism ( = 0.353), depression ( = 0.205), and perceived health ( = 0.133); 2) social participation (R 2 = 0.24): Conscientious-ness ( = –0.344) and Extraversion ( = –0.263); 3) use of communication technologies (R2 = 0.44): age ( = 0.409), type of cohabitation ( = 0.331), cognitive reserve ( = –0.303), and Conscientiousness ( = –0.247); all p < 0.05. The participants with a higher degree of Social Loneliness showed more depressive symptoms (R 2 = 0.133), more memory complaints (R 2 = 0.086), worse perceived health (R 2 = 0.147), lower attentional performance/processing speed (R 2 = 0.094), and more naming difficulties (R 2 = 0.132); all p < 0.05. Conclusions: This research represents an advance in detecting individuals with MCI and an increased risk of developing Social Loneliness, which influences the configuration of the clinical profile of MCI.Publicación Normative data for the Spanish version of the California Verbal Learning Test (TAVEC) from older adults(American Psychological Association, 2022) García Herranz, Sara; Díaz Mardomingo, María del Carmen; Suárez Falcón, Juan Carlos; Rodríguez Fernández, Raquel; Peraita Adrados, Herminia; Venero Núñez, CésarThe aim of this study was to establish normative data for the Spanish version of the California Verbal Learning Test, the Test de Aprendizaje Verbal España-Complutense (TAVEC). Through different subtests, the TAVEC allows verbal learning and episodic memory to be evaluated, an assessment that was carried out on a sample of 382 cognitive healthy Spanish individuals aged 60–90 years old. Unlike the participant’s educational level, their age and sex significantly influenced performance in the TAVEC. We provide tables that allow the scaled scores obtained with this test to be adjusted for age and other tables with the relevant adjustments for sex. The normative data obtained in this study will help more precisely interpret the performance of older Spanish adults in the TAVEC, enhancing the utility of this neuropsychological test to evaluate verbal learning and episodic memory in clinical settings and in relation to healthy aging. (PsycInfo Database Record (c) 2022 APA, all rights reserved)Publicación Validation of the Spanish version of the Memory Failures of Everyday (MFE) questionnaire in older adults using Rasch analysis(Wiley, 2022-02-06) Rodríguez Blázquez, Carmen; Ayala García, Alba; Forjaz, Maria João; García Herranz, Sara; Venero Núñez, César; Rodríguez Fernández, Raquel; Díaz Mardomingo, María del CarmenAim The Memory Failures of Everyday (MFE) is a widely used instrument for assessing memory failure. The aim of the study was to analyze the MFE items using the Rasch model in a sample of cognitively older adults in Spain. Methods A cross-sectional validation study in a sample of 214 healthy people aged ≥60 years who used centers for older people in Madrid (Spain). The MFE for the assessment of memory complaints was used. The following properties of the Rasch model were assessed: data fit, reliability, unidimensionality, local dependence and lack of differential item functioning by gender, age and marital status. Results The MFE showed a good fit to the Rasch model (χ2(140) = 160.2; P = 0.116) and high reliability (person separation index = 0.808). The questionnaire was unidimensional (6.54% t-test; IC binomial = 0.036–0.095). The items showed lack of local dependence between them and differential item functioning. The MFE scores were transformed into linear interval scores with a median of 44.31 and an observed range of 17.9–89.2 (theoretical range: 0–100). Conclusions The MFE is a unidimensional, reliable instrument to assess memory complaints in cognitively healthy older adults in Spain, with usefulness in clinical research and practice. The construct validity of the MFE linear score could not be fully confirmed and this deserves further investigation.Publicación A benchmark for Rey-Osterrieth complex figure test automatic scoring(2024-10-29) Guerrero Martín, Juan; Díaz Mardomingo, María del Carmen; García Herranz, Sara; Martínez Tomás, Rafael; Rincón Zamorano, MarianoThe Rey–Osterrieth complex figure (ROCF) test is a neuropsychological task that can be useful for early detection of cognitive decline in the elderly population. Several computer vision systems have been proposed to automate this complex analysis task, but the lack of public benchmarks does not allow a fair comparison of these systems. To advance in that direction, we present a benchmarking framework for the automatic scoring of the ROCF test that provides: the ROCFD528 dataset, which is the first open dataset of ROCF line drawings; and experimental results obtained by several modern deep learning models, which can be used as a baseline for comparing new proposals. We evaluate different state-of-the-art convolutional neural networks (CNNs) under traditional and transfer learning paradigms. Experimental quantitative results (MAE = 3.448) indicate that a CNN specifically designed for sketches outperforms other state of the art CNN architectures when the number of examples available is limited. This benchmark can also be a paradigmatic example within the broad field of machine learning for the development of efficient and robust models for analyzing line drawings and sketches not only in classification but also in regression tasks.