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e-Spacio es el repositorio institucional de la UNED gestionado por la Biblioteca.
e-Spacio recopila, difunde y preserva de manera permanente la producción docente e investigadora de la UNED con el objetivo de fomentar su visibilidad e impacto.
Participamos en Recolecta, InvestigaM, Google Académico y DialnetPlus.
e-Spacio permite a la comunidad universitaria UNED cumplir con la obligación legislativa de publicar en acceso abierto los resultados de la docencia y la investigación financiada con fondos públicos.
Envíos recientes
A Take Home Laboratory to Support Teaching Electronics: Instructors Perspectives and Technical Revisions, Journal on Teaching Engineering
(University of Porto, 2024-12-02) O´Mahony, Tom; Murray, Michael; Hill, Martin; Onet, Raul; Neag Marius; Torre Cubillo, Luis de la; Zhou, Dao
Three modes dominate engineering labs – in-person, simulation and remote. Take-home laboratories have received comparatively little attention within engineering education. This article reports on qualitative data that was collected, via focus groups with eight staff from a single University, to evaluate the effectiveness of take-home laboratories. The laboratories consisted of a range of embedded development platforms along with a bespoke Home Electronics Laboratory Platform (HELP) that was designed to support the learning of analog and digital electronics in the early years of our programmes. The findings indicate that take-home laboratories can support the development of independent learners and enhance troubleshooting skills. Participants also identified that supporting students in their troubleshooting activity was particularly challenging in a remote environment. We make some suggestions for how take-home laboratories could be used to complement existing laboratory practices.
Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome
(MDPI, 2024-12-14) Borrego Ruiz, Alejandro; Borrego, Juan J.
Background/Objectives: Aging is a natural physiological process involving biological and genetic pathways. Growing evidence suggests that alterations in the epigenome during aging result in transcriptional changes, which play a significant role in the onset of age-related diseases, including cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. For this reason, the epigenetic alterations in aging and age-related diseases have been reviewed, and the major extrinsic factors influencing these epigenetic alterations have been identified. In addition, the role of the gut microbiome and its metabolites as epigenetic modifiers has been addressed. Results: Long-term exposure to extrinsic factors such as air pollution, diet, drug use, environmental chemicals, microbial infections, physical activity, radiation, and stress provoke epigenetic changes in the host through several endocrine and immune pathways, potentially accelerating the aging process. Diverse studies have reported that the gut microbiome plays a critical role in regulating brain cell functions through DNA methylation and histone modifications. The interaction between genes and the gut microbiome serves as a source of adaptive variation, contributing to phenotypic plasticity. However, the molecular mechanisms and signaling pathways driving this process are still not fully understood. Conclusions: Extrinsic factors are potential inducers of epigenetic alterations, which may have important implications for longevity. The gut microbiome serves as an epigenetic effector influencing host gene expression through histone and DNA modifications, while bidirectional interactions with the host and the underexplored roles of microbial metabolites and non-bacterial microorganisms such as fungi and viruses highlight the need for further research.
Unraveling internal friction in a coarse-grained protein model
(AIP Publishing, 2025-03-19) Monago Díaz, Carlos Sebastián; Torre Rodríguez, Jaime Arturo de la; Delgado-Buscalioni, Rafael
Understanding the dynamic behavior of complex biomolecules requires simplified models that not only make computations feasible but also reveal fundamental mechanisms. Coarse-graining (CG) achieves this by grouping atoms into beads, whose stochastic dynamics can be derived using the Mori–Zwanzig formalism, capturing both reversible and irreversible interactions. In liquid, the dissipative bead–bead interactions have so far been restricted to hydrodynamic couplings. However, friction does not only arise from the solvent but, notably, from the internal degrees of freedom missing in the CG beads. This leads to an additional “internal friction” whose relevance is studied in this contribution. By comparing with all-atom molecular dynamics (MD), we neatly show that in order to accurately reproduce the dynamics of a globular protein in water using a CG model, not only a precise determination of elastic couplings and the Stokesian self-friction of each bead is required. Critically, the inclusion of internal friction between beads is also necessary for a faithful representation of protein dynamics. We propose to optimize the parameters of the CG model through a self-averaging method that integrates the CG dynamics with an evolution equation for the CG parameters. This approach ensures that selected quantities, such as the radial distribution function and the time correlation of bead velocities, match the corresponding MD values.