Publicación: Tributyrin reverses the deleterious effect of saturated fat on working memory and synaptic plasticity in juvenile mice: differential effects in males and females
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2024
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info:eu-repo/semantics/openAccess
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Resumen
Short-chain fatty acids, such as butyric acid, derived from the intestinal fermentation of dietary fiber, have been proposed as a treatment for certain pathologies of the central nervous system. Our research group has shown that tributyrin (TB), a butyric acid prodrug, reverses deficits in spatial memory and modulates hippocampal synaptic plasticity. In the present work, diets enriched in either saturated (SOLF; Saturated OiL-enriched Food) or unsaturated (UOLF; Unsaturated OiL-enriched Food) fat were supplied during either 2 h or 8 weeks to 5-week-old male and female mice undergoing a treatment schedule with TB. After the dietary treatment, spatial learning and memory (SLM) was assessed in both the Y-maze and the eight-arm radial maze (RAM). Hippocampal expression of genes involved in glutamatergic transmission as well as synaptic plasticity (long-term potentiation -LTP- and long-term depression -LTD-) were also analyzed. Our results show that 2 h of SOLF intake impaired LTP as well as the performance in the Y-Maze in juvenile male mice whereas no effect was found in females. Moreover, TB reversed both effects in SLM and LTP in males. In the case of chronic intake, both SOLF and UOLF deteriorated SLM measured in the RAM in both sexes whereas TB only reversed LTP impairment induced by SOLF in male mice. These results suggest that TB may have a potentially beneficial influence on learning and memory processes, contingent upon the type of diet and the sex of the individuals.
Descripción
The registered version of this article, first published in “European Journal of Pharmacology, Volume 977, 2024", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.ejphar.2024.176726
La versión registrada de este artículo, publicado por primera vez en “European Journal of Pharmacology, Volume 977, 2024", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.ejphar.2024.176726
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Palabras clave
tributyrin, learning, memory, synaptic plasticity, hippocampus, fatty acid
Citación
Ana Belén Sanz-Martos, María Roca, Mariano Ruiz-Gayo, Nuria del Olmo, Tributyrin reverses the deleterious effect of saturated fat on working memory and synaptic plasticity in juvenile mice: differential effects in males and females, European Journal of Pharmacology, Volume 977, 2024, 176726, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2024.176726
Centro
Facultad de Psicología
Departamento
Psicobiología