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Tributyrin reverses the deleterious effect of saturated fat on working memory and synaptic plasticity in juvenile mice: differential effects in males and females

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dc.contributor.authorSanz Martos, Ana Belén
dc.contributor.authorRoca Outeiro, María
dc.contributor.authorRuiz Gayo, Mariano
dc.contributor.authorOlmo Izquierdo, Nuria Del
dc.contributor.orcidhttps://orcid.org/0000-0002-2805-5076
dc.contributor.orcidhttps://orcid.org/0000-0001-5611-4152
dc.date.accessioned2025-02-11T09:17:13Z
dc.date.available2025-02-11T09:17:13Z
dc.date.issued2024
dc.descriptionThe registered version of this article, first published in “European Journal of Pharmacology, Volume 977, 2024", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.ejphar.2024.176726 La versión registrada de este artículo, publicado por primera vez en “European Journal of Pharmacology, Volume 977, 2024", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.ejphar.2024.176726
dc.description.abstractShort-chain fatty acids, such as butyric acid, derived from the intestinal fermentation of dietary fiber, have been proposed as a treatment for certain pathologies of the central nervous system. Our research group has shown that tributyrin (TB), a butyric acid prodrug, reverses deficits in spatial memory and modulates hippocampal synaptic plasticity. In the present work, diets enriched in either saturated (SOLF; Saturated OiL-enriched Food) or unsaturated (UOLF; Unsaturated OiL-enriched Food) fat were supplied during either 2 h or 8 weeks to 5-week-old male and female mice undergoing a treatment schedule with TB. After the dietary treatment, spatial learning and memory (SLM) was assessed in both the Y-maze and the eight-arm radial maze (RAM). Hippocampal expression of genes involved in glutamatergic transmission as well as synaptic plasticity (long-term potentiation -LTP- and long-term depression -LTD-) were also analyzed. Our results show that 2 h of SOLF intake impaired LTP as well as the performance in the Y-Maze in juvenile male mice whereas no effect was found in females. Moreover, TB reversed both effects in SLM and LTP in males. In the case of chronic intake, both SOLF and UOLF deteriorated SLM measured in the RAM in both sexes whereas TB only reversed LTP impairment induced by SOLF in male mice. These results suggest that TB may have a potentially beneficial influence on learning and memory processes, contingent upon the type of diet and the sex of the individuals.en
dc.description.versionversión publicada
dc.identifier.citationAna Belén Sanz-Martos, María Roca, Mariano Ruiz-Gayo, Nuria del Olmo, Tributyrin reverses the deleterious effect of saturated fat on working memory and synaptic plasticity in juvenile mice: differential effects in males and females, European Journal of Pharmacology, Volume 977, 2024, 176726, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2024.176726
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2024.176726
dc.identifier.issn0014-2999
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25886
dc.journal.titleEuropean Journal of Pharmacology
dc.journal.volume977
dc.language.isoen
dc.page.initial176726
dc.publisherELSEVIER
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordstributyrinen
dc.subject.keywordslearningen
dc.subject.keywordsmemoryen
dc.subject.keywordssynaptic plasticityen
dc.subject.keywordshippocampusen
dc.subject.keywordsfatty aciden
dc.titleTributyrin reverses the deleterious effect of saturated fat on working memory and synaptic plasticity in juvenile mice: differential effects in males and femalesen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicatione9c725e0-840f-4250-befd-b28fe463f64a
relation.isAuthorOfPublicatione5a0115d-4191-4a8a-af4d-6b143cae159b
relation.isAuthorOfPublication1311c3b1-eace-442e-bb19-5b2328963a42
relation.isAuthorOfPublication.latestForDiscoverye9c725e0-840f-4250-befd-b28fe463f64a
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