Persona: Baliyan, Shishir
Cargando...
Dirección de correo electrónico
ORCID
0000-0001-5225-756X
Fecha de nacimiento
Proyectos de investigación
Unidades organizativas
Puesto de trabajo
Apellidos
Baliyan
Nombre de pila
Shishir
Nombre
5 resultados
Resultados de la búsqueda
Mostrando 1 - 5 de 5
Publicación Sex-related differences in the associations between diurnal cortisol pattern and social and emotional loneliness in older adults(Frontiers Media, 2023) Utrera Martínez, Lucía; Sampedro Piquero, Patricia; Díaz Mardomingo, María del Carmen; Baliyan, Shishir; García Herranz, Sara; Suárez Falcón, Juan Carlos; Rodríguez Fernández, Raquel; Valencia Jiménez, Azucena; Venero Núñez, CésarLoneliness is a distressful feeling that can affect mental and physical health, particularly among older adults. Cortisol, the primary hormone of the Hypothalamic-Pituitary-Adrenal axis (HPA-axis), may act as a biological transducer through which loneliness affects health. While most previous studies have evaluated the association between loneliness, as a unidimensional construct, and diurnal cortisol pattern, no research has examined this relationship discriminating between social and emotional loneliness in older adults. As sex differences in the negative mental health outcomes of loneliness have been reported, we also investigated whether diurnal cortisol indices and loneliness associations occur in a sex-specific manner. We analyzed the diurnal cortisol- pattern in 142 community-dwelling, non-depressed, Caucasian older adults (55,6% female) aged 60-90. Social and emotional (family and romantic) loneliness scores were assessed using the Spanish version of the Social and Emotional Loneliness Scale for Adults (SELSA). Five salivary cortisol samples were used to capture key features of the diurnal cortisol pattern, including: awakening and bedtime cortisol levels, awakening response (CAR), post-awakening cortisol output (post-awakening cortisol [i.e., the area under the curve with reference to the ground: AUCG]), total diurnal cortisol release (AUCG), and diurnal cortisol slope (DCS). After controlling for sociodemographic variables, the hierarchical linear multiple regression analyses revealed that in male older adults, higher scores on social and family loneliness were associated with elevated awakening cortisol levels, total diurnal cortisol output, and a steeper diurnal cortisol slope (DCS). However, these associations were not observed in female older adults. In addition, feelings of romantic loneliness were positively associated with bedtime cortisol levels and AUCG in older males. Multilevel growth curve modeling showed that experiencing more social and emotional loneliness predicted higher diurnal cortisol output throughout the day in older male adults. The presence of sex differences in the relationship between cortisol indices and loneliness among older adults holds particular significance for diagnostic and screening procedures. Combining loneliness scales as screening tools with diurnal cortisol measures has the potential to be an effective and cost-efficient approach in identifying higher-risk individuals at early stagesPublicación The effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variability(Elsevier, 2020-06-13) Pulopulos, Matias M.; Schmausser, Maximilian; De Smet, Stefanie; Vanderhasselt, Marie Anne; Baliyan, Shishir; Venero Núñez, César; Baeken, Chris; Raedt, Rudi DeThe prefrontal cortex, and especially the Dorsolateral Prefrontal Cortex (DLPFC), plays an inhibitory role in the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis under stressful situations. Moreover, recent evidence suggests that a sustained DLPFC activation is associated with adaptive stress regulation in anticipation of a stressful event, leading to a reduced stress-induced amygdala response, and facilitating the confrontation with the stressor. However, studies using experimental manipulation of the activity of the DLPFC before a stressor are scarce, and more research is needed to understand the specific role of this brain area in the stress-induced physiological response. This pre-registered study investigated the effect on stress regulation of a single excitatory high frequency (versus sham) repetitive transcranial magnetic stimulation (HF-rTMS) session over the left DLPFC applied before the Trier Social Stress Test in 75 healthy young women (M = 21.05, SD = 2.60). Heart rate variability (HRV) and salivary cortisol were assessed throughout the experimental protocol. The active HF-rTMS and the sham group showed a similar cognitive appraisal of the stress task. No differences in HRV were observed during both the anticipation and the actual confrontation with the stress task and therefore, our results did not reflect DLPFC-related adaptive anticipatory adjustments. Importantly, participants in the active HF-rTMS group showed a lower cortisol response to stress. The effect of left prefrontal HF-rTMS on the stress system provides further critical experimental evidence for the inhibitory role played by the DLPFC in the regulation of the HPA axis.Publicación Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats(Elsevier, 2019-03-29) Pereda Pérez, Inmaculada; Valencia Jiménez, Azucena; Baliyan, Shishir; Núñez, Ángel; Sanz García, Ancor; Rodríguez Fernández, Raquel; Esteban, José Antonio; Venero Núñez, César; Zamora Crespo, Berta; Elsevier; https://orcid.org/0000-0002-8013-4812; https://orcid.org/0000-0002-5024-5108Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.Publicación Stress and empathy – A focus on cortisol as an early biomarker(Universidad Nacional de Educación a Distancia (España). Escuela Internacional de Doctorado. Programa de Doctorado en Psicología de la Salud, 2022) Baliyan, Shishir; Venero Núñez, César; Sandi Pérez, CarmenPublicación Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults(Elsevier, 2023-12) V. Calvo, María; Loria Kohen , Viviana; Díaz Mardomingo, María del Carmen; García Herranz, Sara; Baliyan, Shishir; Carneiro , João Tomé; Colmenarejo, Gonzalo; Visioli, Francesco; Venero Núñez, César; Fontecha, Javier; Elsevier; https://orcid.org/0000-0002-6785-7661; https://orcid.org/0000-0001-8686-3306; https://orcid.org/0000-0002-3597-9234; https://orcid.org/0000-0002-8249-4547; https://orcid.org/0000-0001-5719-2304Cognitive decline is one of the most important consequences of aging and pharmacological therapies had been largely unsuccessful. Other strategies include the use of functional foods to reduce the burden of cognitive decline. The MFGM is an important source of polar lipids and glycoproteins that decline in the aging brain. We have developed a milk drink fortified with MFGM (MFGM-M) as a dietary supplement and studied it in a randomized clinical pilot study. Forty-four > 65-year-old healthy or mildly cognitively impaired subjects received MFGM-M or control milk (CM) for 14 weeks, during which they underwent a battery of cognitive tests. Lipidomic analyzes were also performed. The female participants showed improvement in episodic memory, the ability to recall events in our lives. It is conceivable that any intervention should be started before clinical symptoms manifest, as a preventive measure against cognitive decline. Future long-term studies may shed further light on this point