Publicación: Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats
Fecha
2019-03-29
Autores
Pereda Pérez, Inmaculada
Núñez, Ángel
Sanz García, Ancor
Esteban, José Antonio
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Director/a
Tutor/a
Coordinador/a
Prologuista
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Ilustrador/a
Derechos de acceso
info:eu-repo/semantics/openAccess
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier
Resumen
Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.
Descripción
The registered version of this article, first published in “Neurobiology of Aging,Volume 78,2019,Pages 155-165", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neurobiolaging.2019.02.011
Categorías UNESCO
Palabras clave
Cognition, Corticosterone, Stress, FGF, Hippocampus, LTP, Cognición, Corticosterona, Estrés, FGF, Hipocampo, PLT
Citación
Inmaculada Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, Ancor Sanz-García, Berta Zamora, Raquel Rodríguez-Fernández, José Antonio Esteban, César Venero, "Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats",Neurobiology of Aging,Volume 78,2019,Pages 155-165,https://doi.org/10.1016/j.neurobiolaging.2019.02.011.
Centro
Facultad de Psicología
Departamento
Psicobiología