Publicación:
Schedule-induced alcohol intake during adolescence sex dependently impairs hippocampal synaptic plasticity and spatial memory

Vista sencilla de ítem
dc.contributor.authorSanz Martos, Ana Belén
dc.contributor.authorFuentes Verdugo, Esmeralda
dc.contributor.authorMerino, Beatriz
dc.contributor.authorMorales, Lidia
dc.contributor.authorPérez, Vicente
dc.contributor.authorCapellán, Roberto
dc.contributor.authorPellón, Ricardo
dc.contributor.authorMiguéns, Miguel
dc.contributor.authorOlmo Izquierdo, Nuria Del
dc.date.accessioned2024-10-14T17:11:44Z
dc.date.available2024-10-14T17:11:44Z
dc.date.issued2023-07-10
dc.descriptionThe registered version of this article, first published in Behavioural Brain Research, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.bbr.2023.114576
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Behavioural Brain Research, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.bbr.2023.114576
dc.description.abstractIn a previous study, we demonstrated that intermittent ethanol administration in male adolescent animals impaired hippocampus-dependent spatial memory, particularly under conditions of excessive ethanol administration. In this current study, we subjected adolescent male and female Wistar rats an alcohol schedule-induced drinking (SID) procedure to obtain an elevated rate of alcohol self-administration and assessed their hippocampus-dependent spatial memory. We also studied hippocampal synaptic transmission and plasticity, as well as the expression levels of several genes involved in these mechanisms. Both male and female rats exhibited similar drinking patterns throughout the sessions of the SID protocol reaching similar blood alcohol levels in all the groups. However, only male rats that consumed alcohol showed spatial memory deficits which correlated with inhibition of hippocampal synaptic plasticity as long-term potentiation. In contrast, alcohol did not modify hippocampal gene expression of AMPA and NMDA glutamate receptor subunits, although there are differences in the expression levels of several genes relevant to synaptic plasticity mechanisms underlying learning and memory processes, related to alcohol consumption as Ephb2, sex differences as Pi3k or the interaction of both factors such as Pten. In conclusion, elevated alcohol intake during adolescence seems to have a negative impact on spatial memory and hippocampal synaptic plasticity in a sex dependent manner, even both sexes exhibit similar blood alcohol concentrations and drinking patterns.en
dc.description.versionversión publicada
dc.identifier.citationSanz-Martos, A. B., Fuentes-Verdugo, E., Merino, B., Morales, L., Pérez, V., Capellán, R., Pellón, R., Miguéns, M., & del Olmo, N. (2023). Schedule-induced alcohol intake during adolescence sex dependently impairs hippocampal synaptic plasticity and spatial memory. Behavioural Brain Research, 452. https://doi.org/10.1016/J.BBR.2023.114576
dc.identifier.doihttps://doi.org/10.1016/j.bbr.2023.114576
dc.identifier.issn1872-7549
dc.identifier.urihttps://hdl.handle.net/20.500.14468/24052
dc.journal.titleBehavioural Brain Research
dc.journal.volume452
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject61 Psicología
dc.subject24 Ciencias de la Vida
dc.subject.keywordsbinge drinkingen
dc.subject.keywordsethanolen
dc.subject.keywordsadolescenceen
dc.subject.keywordsmemoryen
dc.subject.keywordsLTPen
dc.subject.keywordssynaptic transmissionen
dc.subject.keywordshippocampusen
dc.titleSchedule-induced alcohol intake during adolescence sex dependently impairs hippocampal synaptic plasticity and spatial memoryen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicatione9c725e0-840f-4250-befd-b28fe463f64a
relation.isAuthorOfPublication1311c3b1-eace-442e-bb19-5b2328963a42
relation.isAuthorOfPublication.latestForDiscoverye9c725e0-840f-4250-befd-b28fe463f64a
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Olmo, Nuria del_Schedule-induced.pdf
Tamaño:
1.84 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
3.62 KB
Formato:
Item-specific license agreed to upon submission
Descripción:
Descargar
Colecciones
Artículos y papers