Publicación: Schedule-induced alcohol intake during adolescence sex dependently impairs hippocampal synaptic plasticity and spatial memory
Fecha
2023-07-10
Autores
Fuentes Verdugo, Esmeralda
Merino, Beatriz
Morales, Lidia
Pérez, Vicente
Capellán, Roberto
Pellón, Ricardo
Miguéns, Miguel
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Director/a
Tutor/a
Coordinador/a
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Derechos de acceso
info:eu-repo/semantics/openAccess
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier
Resumen
In a previous study, we demonstrated that intermittent ethanol administration in male adolescent animals impaired hippocampus-dependent spatial memory, particularly under conditions of excessive ethanol administration. In this current study, we subjected adolescent male and female Wistar rats an alcohol schedule-induced drinking (SID) procedure to obtain an elevated rate of alcohol self-administration and assessed their hippocampus-dependent spatial memory. We also studied hippocampal synaptic transmission and plasticity, as well as the expression levels of several genes involved in these mechanisms. Both male and female rats exhibited similar drinking patterns throughout the sessions of the SID protocol reaching similar blood alcohol levels in all the groups. However, only male rats that consumed alcohol showed spatial memory deficits which correlated with inhibition of hippocampal synaptic plasticity as long-term potentiation. In contrast, alcohol did not modify hippocampal gene expression of AMPA and NMDA glutamate receptor subunits, although there are differences in the expression levels of several genes relevant to synaptic plasticity mechanisms underlying learning and memory processes, related to alcohol consumption as Ephb2, sex differences as Pi3k or the interaction of both factors such as Pten.
In conclusion, elevated alcohol intake during adolescence seems to have a negative impact on spatial memory and hippocampal synaptic plasticity in a sex dependent manner, even both sexes exhibit similar blood alcohol concentrations and drinking patterns.
Descripción
The registered version of this article, first published in Behavioural Brain Research, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.bbr.2023.114576
La versión registrada de este artículo, publicado por primera vez en Behavioural Brain Research, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.bbr.2023.114576
La versión registrada de este artículo, publicado por primera vez en Behavioural Brain Research, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.bbr.2023.114576
Categorías UNESCO
Palabras clave
binge drinking, ethanol, adolescence, memory, LTP, synaptic transmission, hippocampus
Citación
Sanz-Martos, A. B., Fuentes-Verdugo, E., Merino, B., Morales, L., Pérez, V., Capellán, R., Pellón, R., Miguéns, M., & del Olmo, N. (2023). Schedule-induced alcohol intake during adolescence sex dependently impairs hippocampal synaptic plasticity and spatial memory. Behavioural Brain Research, 452. https://doi.org/10.1016/J.BBR.2023.114576
Centro
Facultades y escuelas::Facultad de Psicología
Departamento
Psicobiología