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Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats

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dc.contributor.authorPereda Pérez, Inmaculada
dc.contributor.authorValencia Jiménez, Azucena
dc.contributor.authorBaliyan, Shishir
dc.contributor.authorNúñez, Ángel
dc.contributor.authorSanz García, Ancor
dc.contributor.authorRodríguez Fernández, Raquel
dc.contributor.authorEsteban, José Antonio
dc.contributor.authorVenero Núñez, César
dc.contributor.authorZamora Crespo, Berta
dc.contributor.editorElsevier
dc.contributor.orcidhttps://orcid.org/0000-0002-8013-4812
dc.contributor.orcidhttps://orcid.org/0000-0002-5024-5108
dc.date.accessioned2025-01-24T16:09:17Z
dc.date.available2025-01-24T16:09:17Z
dc.date.issued2019-03-29
dc.descriptionThe registered version of this article, first published in “Neurobiology of Aging,Volume 78,2019,Pages 155-165", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neurobiolaging.2019.02.011
dc.description.abstractSocial isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.en
dc.description.versionversión publicada
dc.identifier.citationInmaculada Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, Ancor Sanz-García, Berta Zamora, Raquel Rodríguez-Fernández, José Antonio Esteban, César Venero, "Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats",Neurobiology of Aging,Volume 78,2019,Pages 155-165,https://doi.org/10.1016/j.neurobiolaging.2019.02.011.
dc.identifier.doihttps://doi.org/10.1016/j.neurobiolaging.2019.02.011
dc.identifier.issnISSN 0197-4580
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25505
dc.journal.titleNeurobiology of Aging
dc.journal.volume78
dc.language.isoen
dc.page.final165
dc.page.initial155
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject32 Ciencias Médicas ::3206 Ciencias de la Nutrición
dc.subject.keywordsCognitionen
dc.subject.keywordsCorticosteroneen
dc.subject.keywordsStressen
dc.subject.keywordsFGFen
dc.subject.keywordsHippocampusen
dc.subject.keywordsLTPen
dc.subject.keywordsCogniciónes
dc.subject.keywordsCorticosteronaes
dc.subject.keywordsEstréses
dc.subject.keywordsFGFes
dc.subject.keywordsHipocampoes
dc.subject.keywordsPLTes
dc.titleSystemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated ratsen
dc.titleLa administración sistémica de un agonista del receptor 1 del factor de crecimiento de fibroblastos rescata el déficit cognitivo en ratas mayores socialmente aisladases
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
person.familyNameValencia Jiménez
person.familyNameBaliyan
person.familyNameRodríguez Fernández
person.familyNameVenero Núñez
person.familyNameZamora Crespo
person.givenNameAzucena
person.givenNameShishir
person.givenNameRaquel
person.givenNameCésar
person.givenNameBerta
person.identifier.orcid0000-0003-0821-7805
person.identifier.orcid0000-0001-5225-756X
person.identifier.orcid0000-0003-4879-3495
relation.isAuthorOfPublication5072adbf-e11c-4ce4-9c6a-918fe0ab3691
relation.isAuthorOfPublication8a052a0d-95db-493f-8166-b6e711ef1d17
relation.isAuthorOfPublication4ee75ccf-e2b9-4517-8dfd-97c0f925ecbc
relation.isAuthorOfPublicationa021663c-0586-44a7-898c-3dc7811295ac
relation.isAuthorOfPublication11d24eec-7d4d-435e-8ff6-b7c666f9826e
relation.isAuthorOfPublication.latestForDiscovery5072adbf-e11c-4ce4-9c6a-918fe0ab3691
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