Publicación:
Activity-based anorexia alters hypothalamic POMC and orexin populations in male rats

Vista sencilla de ítem
dc.contributor.authorPinos, Helena
dc.contributor.authorSánchez Serrano, Ricardo
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorFernández García, José Manuel
dc.contributor.authorGarcía Úbeda, Rocío
dc.contributor.authorPaz Regidor, Ana María de
dc.contributor.authorLópez Tolsa Gómez, Gabriela Eugenia
dc.contributor.authorVidal García, Pedro
dc.contributor.authorGutiérrez Ferre, Valeria Edith
dc.contributor.authorPellón Suárez de Puga, Ricardo
dc.contributor.authorCollado Guirao, Paloma
dc.date.accessioned2024-12-27T12:10:13Z
dc.date.available2024-12-27T12:10:13Z
dc.date.issued2022-08-11
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Behavioural Brain Research, Volume 436, 2023, 114055, ISSN 0166-4328, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.bbr.2022.114055. The registered version of this article, first published in Behavioral Brain Research, Volume 436, 2023, 114055, ISSN 0166-4328, is available online at the publisher's website: https://doi .org/10.1016/j.bbr.2022.114055.
dc.description.abstractThe objective of this study was to investigate the orexin and POMC populations in the hypothalamic nuclei of male Wistar rats after the activity-based anorexia (ABA) procedure. Four groups were established based on food restriction and activity: activity (A), ABA, diet (D) and control (C). The ABA protocol consisted of free access to a running wheel for a period of 22 h and access to food for 1 h. When the animals in the ABA group reached the ABA criterion, were sacrificed, and their brains were collected and serially sectioned. The free-floating sections were processed for orexin and POMC immunostaining. The number of orexin A-ir cells in the perifornical-dorsomedial-hypothalamus continuum (PFD) and lateral hypothalamus (LH) and the number of POMC-ir cells in the arcuate nucleus (Arc) were estimated. Data on food intake, body weight and wheel turns were also analyzed. The ABA procedure caused a significant decrease in body weight along with a significant increase in activity. Moreover, at the end of the ABA procedure, the number of POMC-ir cells decreased in the Arc in the A group, and significantly more in the ABA group, and the number of orexin A-ir positive cells decreased in the LH in D and ABA groups. The differential decrease in POMC in the ABA group emphasizes the importance of the melanocortin system in the maintenance of ABA, but more research is needed to elucidate the involvement of this peptide in the mechanism that promotes and maintains anorexia nervosa and how increased activity may interact with all these processes.en
dc.description.versionversión publicada
dc.identifier.citationPinos H., Sánchez-Serrano R., Carrillo B., Fernández-García JM., García-Úbeda R., De Paz A., López-Tolsa GE., Vidal P., Gutiérrez-Ferre V., Pellón R., Collado P. (2023) Activity-based anorexia alters hypothalamic POMC and orexin populations in male rats. Behav. Brain Res., 436: 114055. FI: 3.352; Q2, https://doi.org/10.1016/j.bbr.2022.114055
dc.identifier.doihttps://doi.org/10.1016/j.bbr.2022.114055
dc.identifier.issn0166-4328
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25061
dc.journal.titleBehavioural Brain Research
dc.journal.volume436
dc.language.isoes
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsActivity-based anorexiaen
dc.subject.keywordsPOMCen
dc.subject.keywordsorexinen
dc.subject.keywordsarcuate nucleusen
dc.subject.keywordsmale raten
dc.subject.keywordslateral hypothalamusen
dc.titleActivity-based anorexia alters hypothalamic POMC and orexin populations in male ratsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublicationf6f9a9e6-3e33-4985-b829-a5695cfd56dc
relation.isAuthorOfPublicationcd014de7-025a-4bfa-8621-c28b6d8821d6
relation.isAuthorOfPublicationba8ed850-8d02-456c-8d85-9290e6c6bab9
relation.isAuthorOfPublication013ec176-4e5f-43bb-95df-1d11e98c39e9
relation.isAuthorOfPublication8edbde84-9307-47aa-9ef8-5e85de175df6
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Pinos et al Activity-based.pdf
Tamaño:
5.77 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
3.62 KB
Formato:
Item-specific license agreed to upon submission
Descripción:
Descargar
Colecciones
Artículos y papers