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Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner

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dc.contributor.authorSanz Martos, Ana Belén
dc.contributor.authorRoca Outeiro, María
dc.contributor.authorPlaza, Adrián
dc.contributor.authorMerino, Beatriz
dc.contributor.authorRuiz Gayo, Mariano
dc.contributor.authorOlmo Izquierdo, Nuria Del
dc.contributor.orcidhttps://orcid.org/0000-0002-5316-5090
dc.contributor.orcidhttps://orcid.org/0000-0002-2186-070X
dc.contributor.orcidhttps://orcid.org/0000-0002-2805-5076
dc.contributor.orcidhttps://orcid.org/0000-0001-5611-4152
dc.date.accessioned2025-02-11T09:36:26Z
dc.date.available2025-02-11T09:36:26Z
dc.date.issued2024-11-15
dc.descriptionThe registered version of this article, first published in “Neuropharmacology, Volume 259, 2024", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neuropharm.2024.110108 La versión registrada de este artículo, publicado por primera vez en “Neuropharmacology, Volume 259, 2024", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuropharm.2024.110108
dc.description.abstractConsumption of saturated fat-enriched diets during adolescence has been closely associated with the reduction of hippocampal synaptic plasticity and the impairment of cognitive function. Nevertheless, the effect of long-term intake of these foods has not yet been studied. In the present study, we have investigated the effect of a treatment, lasting for 40 weeks, with a diet enriched in saturated fat (SOLF) on i) spatial learning and memory, ii) hippocampal synaptic transmission and plasticity, and iii) hippocampal gene expression levels in aged male and female mice. Our findings reveal that SOLF has a detrimental impact on spatial memory and synaptic plasticity mechanisms, such as long-term potentiation (LTP), and downregulates Gria1 expression specifically in males. In females, SOLF downregulates the gene expression of Gria1/2/3 and Grin1/2A/2B glutamate receptor subunits as well as some proinflammatory interleukins. These findings highlight the importance of considering sex-specific factors when assessing the long-term effects of high-fat diets on cognition and brain plasticity.en
dc.description.versionversión publicada
dc.identifier.citationAna Belén Sanz-Martos, María Roca, Adrián Plaza, Beatriz Merino, Mariano Ruiz-Gayo, Nuria del Olmo, Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner, Neuropharmacology, Volume 259, 2024, 110108, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2024.110108
dc.identifier.doihttps://doi.org/10.1016/j.neuropharm.2024.110108
dc.identifier.issn0028-3908
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25888
dc.journal.titleNeuropharmacology
dc.journal.volume259
dc.language.isoen
dc.page.initial110108
dc.publisherELSEVIER
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordssaturated fat dietsen
dc.subject.keywordsmemoryen
dc.subject.keywordssynaptic plasticityen
dc.subject.keywordshippocampusen
dc.subject.keywordsagingen
dc.titleLong-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manneren
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublicatione5a0115d-4191-4a8a-af4d-6b143cae159b
relation.isAuthorOfPublication1311c3b1-eace-442e-bb19-5b2328963a42
relation.isAuthorOfPublication.latestForDiscoverye9c725e0-840f-4250-befd-b28fe463f64a
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