Publicación: Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner
Fecha
2024-11-15
Autores
Plaza, Adrián
Merino, Beatriz
Ruiz Gayo, Mariano
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info:eu-repo/semantics/openAccess
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Resumen
Consumption of saturated fat-enriched diets during adolescence has been closely associated with the reduction of hippocampal synaptic plasticity and the impairment of cognitive function. Nevertheless, the effect of long-term intake of these foods has not yet been studied. In the present study, we have investigated the effect of a treatment, lasting for 40 weeks, with a diet enriched in saturated fat (SOLF) on i) spatial learning and memory, ii) hippocampal synaptic transmission and plasticity, and iii) hippocampal gene expression levels in aged male and female mice. Our findings reveal that SOLF has a detrimental impact on spatial memory and synaptic plasticity mechanisms, such as long-term potentiation (LTP), and downregulates Gria1 expression specifically in males. In females, SOLF downregulates the gene expression of Gria1/2/3 and Grin1/2A/2B glutamate receptor subunits as well as some proinflammatory interleukins. These findings highlight the importance of considering sex-specific factors when assessing the long-term effects of high-fat diets on cognition and brain plasticity.
Descripción
The registered version of this article, first published in “Neuropharmacology, Volume 259, 2024", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neuropharm.2024.110108
La versión registrada de este artículo, publicado por primera vez en “Neuropharmacology, Volume 259, 2024", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuropharm.2024.110108
Categorías UNESCO
Palabras clave
saturated fat diets, memory, synaptic plasticity, hippocampus, aging
Citación
Ana Belén Sanz-Martos, María Roca, Adrián Plaza, Beatriz Merino, Mariano Ruiz-Gayo, Nuria del Olmo, Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner, Neuropharmacology, Volume 259, 2024, 110108, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2024.110108
Centro
Facultad de Psicología
Departamento
Psicobiología