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Impact of single and combined exposure to priority pollutants on gene expression and post-embryonic development in Drosophila melanogaster

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dc.contributor.authorFrat, Laëtitia
dc.contributor.authorChertemps, Thomas
dc.contributor.authorPesce, Elise
dc.contributor.authorBozzolan, Françoise
dc.contributor.authorDacher, Matthieu
dc.contributor.authorPlanello Carro, María del Rosario
dc.contributor.authorHerrero Felipe, Óscar
dc.contributor.authorLlorente Ortega, Lola
dc.contributor.authorMoers, Didier
dc.contributor.authorSiaussat, David
dc.contributor.orcidhttps://orcid.org/0000-0002-6962-1839
dc.contributor.orcidhttps://orcid.org/0000-0001-8607-2889
dc.contributor.orcidhttps://orcid.org/0000-0002-1716-6889
dc.date.accessioned2025-01-28T10:10:01Z
dc.date.available2025-01-28T10:10:01Z
dc.date.issued2023
dc.descriptionThe registered version of this article, first published in “Ecotoxicology and Environmental Safety vol. 250, 2023", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.ecoenv.2022.114491 La versión registrada de este artículo, publicado por primera vez en “Ecotoxicology and Environmental Safety vol. 250, 2023", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.ecoenv.2022.114491
dc.description.abstractMany priority pollutants are concentrated in the environment due to human activity. Most are highly toxic to various organisms, including endocrine disruptors EDCs, aromatic polycyclic hydrocarbons PAHs, pesticides. While the effects of single and binary exposure have been widely explored, several pollutants can be simultaneously present at the same time in the environment, in in more or less polluted matrices. Effective pollution control requires the presence and sources of contamination to be identified. Previously we used Drosophila melanogaster to investigate metal pollution. Here, we re-used Drosophila to identify the biomarkers of pollution, and to determine if they can be used for specific types of pollution. Single and combined exposure of Bis(2-ethylhexyl) phthalate (DEHP), bisphenol A, nonylphenol, benzo(a)pyrene, and glyphosate was investigated. The impact of these pollutants on post-embryonic development and the expression pattern of 38 molecular targets were examined using qPCR. During single exposure, different profiles were observed at the molecular level. In complex mixtures, the expression profile resembled that of bisphenol A. In contrast, relatively specific gene expression profiles were obtained for the effects of each pollutant separately. While direct pollutant-gene profiling remains difficult in mixtures, molecular biology analyses enhance pollution monitoring, and should be incorporated in toxicological studies.en
dc.description.versionversión publicada
dc.identifier.citationLaëtitia Frat, Thomas Chertemps, Elise Pesce, Françoise Bozzolan, Matthieu Dacher, Rosario Planello, Oscar Herrero, Lola Llorente, Didier Moers, David Siaussat, Impact of single and combined exposure to priority pollutants on gene expression and post-embryonic development in Drosophila melanogaster, Ecotoxicology and Environmental Safety, Volume 250, 2023, 114491, ISSN 0147-6513, https://doi.org/10.1016/j.ecoenv.2022.114491
dc.identifier.doihttps://doi.org/10.1016/j.ecoenv.2022.114491
dc.identifier.issn0147-6513
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25578
dc.journal.titleEcotoxicology and Environmental Safety
dc.journal.volume250
dc.language.isoen
dc.publisherELSEVIER
dc.relation.centerFacultades y escuelas::Facultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.keywordsendocrine disruptorsen
dc.subject.keywordsbenzo(a)pyreneen
dc.subject.keywordsglyphosateen
dc.subject.keywordsmixtureen
dc.subject.keywordsinsecten
dc.subject.keywordsgene expressionen
dc.subject.keywordswastewateren
dc.titleImpact of single and combined exposure to priority pollutants on gene expression and post-embryonic development in Drosophila melanogasteren
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublication1de7b6f9-dd97-4518-8f0e-3c54768bfe6a
relation.isAuthorOfPublication16da09a8-34db-4259-90d7-36928325faff
relation.isAuthorOfPublication.latestForDiscovery1de7b6f9-dd97-4518-8f0e-3c54768bfe6a
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