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Preclinical Validation of an Electrochemical Sensor for Alcohol Consumption Monitoring in a Polydrug Self-Administration Animal Model

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dc.contributor.authorGarrido Matilla, Lucía
dc.contributor.authorMaría Hormigos, Roberto
dc.contributor.authorMonago Maraña, Olga
dc.contributor.authorMarcos, Alberto
dc.contributor.authorAmbrosio Flores, Emilio
dc.contributor.authorGonzález Crevillén, Agustín
dc.date.accessioned2025-10-21T14:55:37Z
dc.date.available2025-10-21T14:55:37Z
dc.date.issued2025-03-08
dc.descriptionThe registered version of this article, first published in “Chemosensors, 13(3), 97", is available online at the publisher's website: MDPI,https://doi.org/10.3390/chemosensors13030097
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en “Chemosensors, 13(3), 97", está disponible en línea en el sitio web del editor: MDPI, https://doi.org/10.3390/chemosensors13030097
dc.description.abstractAn electrochemical sensor for identification and monitoring of alcoholism was preclinically validated by analyzing plasma from polydrug-consuming rats (alcohol and cocaine). The sensor measures by adsorptive transfer square wave voltammetry the glycosylation level of transferrin, which is an alcoholism biomarker, through a recently reported parameter called the electrochemical index of glycosylation (EIG). Three rat groups were designed: saline group, cocaine group, and cocaine–alcohol group. Moreover, two periods of withdrawal were studied, after 2 days and 30 days. The alcohol–cocaine group after 2 days of withdrawal showed significantly lower EIG values (p < 0.1) than the rest of groups and also alcohol–cocaine group after 30 days of withdrawal, so the sensor was able to identify the alcohol consumption in rats and to monitor the recovery of glycosylation level after 30 days of withdrawal, even combined with cocaine. Furthermore, the effect of sex was also considered. Receiver operating characteristic (ROC) curves were developed for each sex and the corresponding cut-off values were determined. The sensor showed a clinical sensitivity of 70% for male and 75% for female, and a specificity of 67% for both sexes. This preclinical validation demonstrated the possibilities of this sensor for point of care testing of alcoholism, even in cocaine addicts, making it a potential tool for diagnosis and monitoring of alcohol consumption in detox treatments for humans.en
dc.description.versionversión publicada
dc.identifier.citationGarrido-Matilla, L., María-Hormigos, R., Monago-Maraña, O., Marcos, A., Ambrosio, E., & Crevillen, A. G. (2025). Preclinical Validation of an Electrochemical Sensor for Alcohol Consumption Monitoring in a Polydrug Self-Administration Animal Model. Chemosensors, 13(3), 97. https://doi.org/10.3390/chemosensors13030097
dc.identifier.doihttps://doi.org/10.3390/chemosensors13030097
dc.identifier.issneISSN: 2227-9040
dc.identifier.urihttps://hdl.handle.net/20.500.14468/30561
dc.journal.issue3
dc.journal.titleChemosensors
dc.journal.volume13
dc.language.isoen
dc.page.initial97
dc.publisherMDPI
dc.relation.centerFacultad de Ciencias
dc.relation.departmentCiencias Analíticas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/deed.es
dc.subject3303.09 Operaciones electroquímicas
dc.subject2301 Química analítica
dc.subject.keywordsalcoholismen
dc.subject.keywordspoint-of-care testingen
dc.subject.keywordscarbohydrate-deficient transferrinen
dc.subject.keywordssensoren
dc.subject.keywordspolydrugen
dc.subject.keywordsdiagnosisen
dc.subject.keywordsrat plasmaen
dc.titlePreclinical Validation of an Electrochemical Sensor for Alcohol Consumption Monitoring in a Polydrug Self-Administration Animal Modelen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery36266e9e-7e54-4d1f-a995-ddfd9f7372e3
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