Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome

Borrego Ruiz, Alejandro; Borrego, Juan J.

Publicación:
Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome

dc.contributor.author	Borrego Ruiz, Alejandro
dc.contributor.author	Borrego, Juan J.
dc.date.accessioned	2025-06-27T15:09:56Z
dc.date.available	2025-06-27T15:09:56Z
dc.date.issued	2024-12-14
dc.description	The registered version of this article, first published by MDPI in “Genes, 15(12), 1599", is available online at the publisher's website: Universidad nacional de Educación a Distancia, https://doi.org/10.3390/genes15121599
dc.description.abstract	Background/Objectives: Aging is a natural physiological process involving biological and genetic pathways. Growing evidence suggests that alterations in the epigenome during aging result in transcriptional changes, which play a significant role in the onset of age-related diseases, including cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. For this reason, the epigenetic alterations in aging and age-related diseases have been reviewed, and the major extrinsic factors influencing these epigenetic alterations have been identified. In addition, the role of the gut microbiome and its metabolites as epigenetic modifiers has been addressed. Results: Long-term exposure to extrinsic factors such as air pollution, diet, drug use, environmental chemicals, microbial infections, physical activity, radiation, and stress provoke epigenetic changes in the host through several endocrine and immune pathways, potentially accelerating the aging process. Diverse studies have reported that the gut microbiome plays a critical role in regulating brain cell functions through DNA methylation and histone modifications. The interaction between genes and the gut microbiome serves as a source of adaptive variation, contributing to phenotypic plasticity. However, the molecular mechanisms and signaling pathways driving this process are still not fully understood. Conclusions: Extrinsic factors are potential inducers of epigenetic alterations, which may have important implications for longevity. The gut microbiome serves as an epigenetic effector influencing host gene expression through histone and DNA modifications, while bidirectional interactions with the host and the underexplored roles of microbial metabolites and non-bacterial microorganisms such as fungi and viruses highlight the need for further research.	en
dc.description.version	versión publicada
dc.identifier.citation	Borrego-Ruiz, A., & Borrego, J. J. (2024). Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome. Genes, 15(12), 1599. https://doi.org/10.3390/genes15121599
dc.identifier.doi	https://doi.org/10.3390/genes15121599
dc.identifier.issn	2073-4425
dc.identifier.uri	https://hdl.handle.net/20.500.14468/26949
dc.journal.issue	12
dc.journal.title	Genes
dc.journal.volume	15
dc.language.iso	en
dc.publisher	MDPI
dc.relation.center	Facultades y escuelas::Facultad de Psicología
dc.relation.department	PSICOLOGÍA SOCIAL Y DE LAS ORGANIZACIONES
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.subject	63 Sociología::6302 Sociología Experimental::6302.02 Psicología social
dc.subject	24 Ciencias de la Vida
dc.subject.keywords	epigenetics	en
dc.subject.keywords	aging	en
dc.subject.keywords	gut microbiome	en
dc.subject.keywords	microbial metabolites	en
dc.subject.keywords	neurodegenerative diseases	en
dc.subject.keywords	extrinsic factors	en
dc.title	Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome	en
dc.type	artículo	es
dc.type	journal article	en
dspace.entity.type	Publication
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relation.isAuthorOfPublication.latestForDiscovery	4056d333-e1b2-4759-8b5a-af6f4e202fd8