Fecha
2024-12-14
Editor/a
Director/a
Tutor/a
Coordinador/a
Prologuista
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Derechos de acceso
info:eu-repo/semantics/openAccess
Título de la revista
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Editor
MDPI
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Resumen
Background/Objectives: Aging is a natural physiological process involving biological and genetic pathways. Growing evidence suggests that alterations in the epigenome during aging result in transcriptional changes, which play a significant role in the onset of age-related diseases, including cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. For this reason, the epigenetic alterations in aging and age-related diseases have been reviewed, and the major extrinsic factors influencing these epigenetic alterations have been identified. In addition, the role of the gut microbiome and its metabolites as epigenetic modifiers has been addressed. Results: Long-term exposure to extrinsic factors such as air pollution, diet, drug use, environmental chemicals, microbial infections, physical activity, radiation, and stress provoke epigenetic changes in the host through several endocrine and immune pathways, potentially accelerating the aging process. Diverse studies have reported that the gut microbiome plays a critical role in regulating brain cell functions through DNA methylation and histone modifications. The interaction between genes and the gut microbiome serves as a source of adaptive variation, contributing to phenotypic plasticity. However, the molecular mechanisms and signaling pathways driving this process are still not fully understood. Conclusions: Extrinsic factors are potential inducers of epigenetic alterations, which may have important implications for longevity. The gut microbiome serves as an epigenetic effector influencing host gene expression through histone and DNA modifications, while bidirectional interactions with the host and the underexplored roles of microbial metabolites and non-bacterial microorganisms such as fungi and viruses highlight the need for further research.
Descripción
The registered version of this article, first published by MDPI in “Genes, 15(12), 1599", is available online at the publisher's website: Universidad nacional de Educación a Distancia, https://doi.org/10.3390/genes15121599
Categorías UNESCO
Palabras clave
epigenetics, aging, gut microbiome, microbial metabolites, neurodegenerative diseases, extrinsic factors
Citación
Borrego-Ruiz, A., & Borrego, J. J. (2024). Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome. Genes, 15(12), 1599. https://doi.org/10.3390/genes15121599
Centro
Facultades y escuelas::Facultad de Psicología
Departamento
PSICOLOGÍA SOCIAL Y DE LAS ORGANIZACIONES