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Effect of environmental stressors on the mRNA expression of ecdysone cascade genes in Chironomus riparius

dc.contributor.authorFuente Rubio, Mercedes de la
dc.contributor.authorMartín Folgar, Raquel
dc.contributor.authorMartínez Paz, Pedro
dc.contributor.authorCortés Rubio, María Estrella del Perpetuo
dc.contributor.authorMartínez Guitarte, José Luis
dc.contributor.authorMorales Camarzana, Consolación Mónica
dc.contributor.orcidhttps://orcid.org/0000-0002-5772-8153
dc.date.accessioned2024-10-03T17:13:07Z
dc.date.available2024-10-03T17:13:07Z
dc.date.issued2021-09-13
dc.descriptionThe registered version of this article, first published in Environmental Science and Pollution Research , is available online at the publisher's website: Springer, https://doi.org/10.1007/s11356-021-16339-3
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Environmental Science and Pollution Research , está disponible en línea en el sitio web del editor: Springer, https://doi.org/10.1007/s11356-021-16339-3
dc.description.abstractChemical compounds produced by humans are continuously reaching the environment. In this work, we characterised the expression patterns of important endocrine-related genes involved in the ecdysone pathway in the fourth larval instar of the model species Chironomus riparius after exposure to three chemicals: ethinyl oestradiol (EE), nonylphenol (NP) and bis(tributyltin) oxide (TBTO). We used real-time PCR to analyse the gene expression levels of ecdysone receptor (EcR) and ultraspiracle (usp), two genes that encode the dimerising partners of the functional ecdysone receptor; the orphan receptor ERR (oestrogen-related receptor), with an unknown function in invertebrates; and E74, an early response gene induced by ecdysteroids. We estimated the bioaccumulation potential, bioavailability and physicochemical properties of these chemicals, together with a number of other exogenous agents known to interfere with the hormonal system. We also provide a review of previous transcriptional studies showing the effect of all these chemicals on ecdysone cascade genes. This analysis provides useful data for future ecotoxicological studies involving invertebrate species.en
dc.description.versionversión publicada
dc.identifier.citationde la Fuente, ., Folgar, R.M., Martínez-Paz, P. et al. Effect of environmental stressors on the mRNA expression of ecdysone cascade genes in Chironomus riparius. Environ Sci Pollut Res 29, 10210–10221 (2022). https://doi.org/10.1007/s11356-021-16339-3
dc.identifier.doihttps://doi.org/10.1007/s11356-021-16339-3
dc.identifier.issn1614-7499
dc.identifier.urihttps://hdl.handle.net/20.500.14468/23892
dc.journal.titleEnvironmental Science and Pollution Research
dc.journal.volume29
dc.language.isoen
dc.page.final10221
dc.page.initial10210
dc.publisherSpringer
dc.relation.centerFacultades y escuelas::Facultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject24 Ciencias de la Vida
dc.subject.keywordsendocrine-disrupting chemicals (EDCs)en
dc.subject.keywordschironomus ripariusen
dc.subject.keywordstoxicityen
dc.subject.keywordstranscriptional responseen
dc.titleEffect of environmental stressors on the mRNA expression of ecdysone cascade genes in Chironomus ripariusen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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