Publicación: Effect of environmental stressors on the mRNA expression of ecdysone cascade genes in Chironomus riparius
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2021-09-13
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info:eu-repo/semantics/openAccess
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Springer
Resumen
Chemical compounds produced by humans are continuously reaching the environment. In this work, we characterised the expression patterns of important endocrine-related genes involved in the ecdysone pathway in the fourth larval instar of the model species Chironomus riparius after exposure to three chemicals: ethinyl oestradiol (EE), nonylphenol (NP) and bis(tributyltin) oxide (TBTO). We used real-time PCR to analyse the gene expression levels of ecdysone receptor (EcR) and ultraspiracle (usp), two genes that encode the dimerising partners of the functional ecdysone receptor; the orphan receptor ERR (oestrogen-related receptor), with an unknown function in invertebrates; and E74, an early response gene induced by ecdysteroids. We estimated the bioaccumulation potential, bioavailability and physicochemical properties of these chemicals, together with a number of other exogenous agents known to interfere with the hormonal system. We also provide a review of previous transcriptional studies showing the effect of all these chemicals on ecdysone cascade genes. This analysis provides useful data for future ecotoxicological studies involving invertebrate species.
Descripción
The registered version of this article, first published in Environmental Science and Pollution Research , is available online at the publisher's website: Springer, https://doi.org/10.1007/s11356-021-16339-3
La versión registrada de este artículo, publicado por primera vez en Environmental Science and Pollution Research , está disponible en línea en el sitio web del editor: Springer, https://doi.org/10.1007/s11356-021-16339-3
La versión registrada de este artículo, publicado por primera vez en Environmental Science and Pollution Research , está disponible en línea en el sitio web del editor: Springer, https://doi.org/10.1007/s11356-021-16339-3
Categorías UNESCO
Palabras clave
endocrine-disrupting chemicals (EDCs), chironomus riparius, toxicity, transcriptional response
Citación
de la Fuente, ., Folgar, R.M., Martínez-Paz, P. et al. Effect of environmental stressors on the mRNA expression of ecdysone cascade genes in Chironomus riparius. Environ Sci Pollut Res 29, 10210–10221 (2022). https://doi.org/10.1007/s11356-021-16339-3
Centro
Facultades y escuelas::Facultad de Ciencias
Departamento
Física Matemática y de Fluídos