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Functional neurological disorder and gut microbiome: Casual or causal relationship?

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dc.contributor.authorBorrego Ruiz, Alejandro
dc.contributor.authorBorrego, Juan J.
dc.contributor.authorBorrego Ruiz, Alejandro
dc.date.accessioned2025-06-11T07:27:32Z
dc.date.available2025-06-11T07:27:32Z
dc.date.issued2024-09-19
dc.descriptionThe registered version of this article, first published in “Journal of Clinical and Basic Psychosomatics, 2, 2024", is available online at the publisher's website: AccScience Publishing, https://doi.org/10.36922/jcbp.4160 La versión registrada de este artículo, publicado por primera vez en “Journal of Clinical and Basic Psychosomatics, 2, 2024", está disponible en línea en el sitio web del editor: AccScience Publishing, https://doi.org/10.36922/jcbp.4160
dc.description.abstractFunctional neurological disorder (FND), or conversion disorder, is a psychosomatic condition that affects the voluntary motor and/or sensory functions of the patient. Its origin is not yet fully understood, but the main risk factors related to this disorder include exposure to recent psychological stressors and previous experience of aversive episodes during childhood, such as abuse, family dysfunction, and neglect. The symptoms of FND result from complex interactions involving the central nervous system and also the endocrine and immune systems. In this work, we hypothesized the relationship between the gut microbiome and the pathophysiology of FND because both share several common features, such as the effects of neurotransmitters, the hippocampal expression of brain-derived neurotrophic factor, and the inflammatory responses. Based on these common aspects, we suggested that stress, gut microbiome, and inflammation factors induce chronic and systemic inflammation of the brain causing neurological disorders, including FND. More specific studies are warranted to validate the casual or causal relationship between FND and the gut microbiome.en
dc.description.versionversión publicada
dc.identifier.citationBorrego-Ruiz, A., & Borrego, J.J. (2024). Functional neurological disorder and gut microbiome: Casual or causal relationship?. Journal of Clinical and Basic Psychosomatics, 2(4), 4160. https://doi.org/10.36922/jcbp.4160
dc.identifier.doihttps://doi.org/10.36922/jcbp.4160
dc.identifier.issn2972-4414
dc.identifier.urihttps://hdl.handle.net/20.500.14468/26883
dc.journal.issue4
dc.journal.titleJournal of Clinical and Basic Psychosomatics
dc.journal.volume2
dc.language.isoen
dc.page.initial4160
dc.publisherAccScience Publishing
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicología Social y de las Organizaciones
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsfunctional neurological disorderen
dc.subject.keywordsconversion disorderen
dc.subject.keywordsgut microbiomeen
dc.subject.keywordsneurotransmittersen
dc.subject.keywordsmicrobial metabolitesen
dc.subject.keywordsneuroinflammationen
dc.titleFunctional neurological disorder and gut microbiome: Casual or causal relationship?en
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
person.familyNameBorrego Ruiz
person.givenNameAlejandro
person.identifier.orcidhttps://orcid.org/0000-0002-4699-3031
relation.isAuthorOfPublication4056d333-e1b2-4759-8b5a-af6f4e202fd8
relation.isAuthorOfPublication.latestForDiscovery4056d333-e1b2-4759-8b5a-af6f4e202fd8
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