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Neonatal inhibition of androgen activity alters the programming of body weight and orexinergic peptides differentially in male and female rats

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dc.contributor.authorFernández García, José Manuel
dc.contributor.authorGrassi, Daniela
dc.contributor.authorBlanco, Noemí
dc.contributor.authorBallesta, Antonio
dc.contributor.authorArevalo, María de los Ángeles
dc.contributor.authorPino Osuna, María José
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorGarcía Úbeda, Rocío
dc.contributor.authorPrimo Chulvi, Ulises
dc.contributor.authorCollado Guirao, Paloma
dc.date.accessioned2024-06-11T15:15:31Z
dc.date.available2024-06-11T15:15:31Z
dc.date.issued2024-02-13
dc.description.abstractThe involvement of androgens in the regulation of energy metabolism has been demonstrated. The main objective of the present research was to study the involvement of androgens in both the programming of energy metabolism and the regulatory peptides associated with feeding. For this purpose, androgen receptors and the main metabolic pathways of testosterone were inhibited during the first five days of postnatal life in male and female Wistar rats. Pups received a daily s.c. injection from the day of birth, postnatal day (P) 1, to P5 of Flu- tamide (a competitive inhibitor of androgen receptors), Letrozole (an aromatase inhibitor), Finasteride (a 5- alpha-reductase inhibitor) or vehicle. Body weight, food intake and fat pads were measured. Moreover, hypo- thalamic Agouti-related peptide (AgRP), neuropeptide Y (NPY), orexin, and proopiomelanocortin (POMC) were analyzed by quantitative real-time polymerase chain reaction assay. The inhibition of androgenic activity during the first five days of life produced a significant decrease in body weight in females at P90 but did not affect this parameter in males. Moreover, the inhibition of aromatase decreased hypothalamic AgRP mRNA levels in males while the inhibition of 5α-reductase decreased hypothalamic AgRP and orexin mRNA levels in female rats. Finally, food intake and visceral fat, but not subcutaneous fat, were affected in both males and females depending on which testosterone metabolic pathway was inhibited. Our results highlight the differential involvement of androgens in the programming of energy metabolism as well as the AgRP and orexin systems during development in male and female ratsen
dc.identifier.doihttps://doi.org/10.1016/j.brainresbull.2024.110898
dc.identifier.issn0361-9230
dc.identifier.urihttps://hdl.handle.net/20.500.14468/22422
dc.journal.titleBrain Research Bulletin
dc.journal.volume208
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsAndrogens
dc.subject.keywordsProgramming
dc.subject.keywordsOrexigenic peptides
dc.subject.keywordsSex differences
dc.subject.keywordsRat
dc.titleNeonatal inhibition of androgen activity alters the programming of body weight and orexinergic peptides differentially in male and female ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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