Publicación: Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats
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2019-06-01
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info:eu-repo/semantics/openAccess
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Elsevier
Resumen
The ovarian hormone 17β-estradiol is known to regulate the release, expression and immunoreactivity of arginine-vasopressin (AVP) in the supraoptic and paraventricular hypothalamic nuclei of rodents. Previous studies have shown that estrogen receptor α is involved in the effects of chronic estradiol administration on arginine-vasopressin immunoreactivity in the female rat hypothalamus. In this study we have examined the effect of an acute administration of estradiol or specific agonists for estrogen receptors α, β and G protein-coupled estrogen receptor 1 on the immunoreactivity of arginine-vasopressin in the hypothalamus of adult ovariectomized female rats. Acute estradiol administration resulted in a significant decrease in the number of arginine-vasopressin immunoreactive neurons in the supraoptic and paraventricular nuclei after 24 h. The effects of the specific estrogen receptors agonists suggest that the action of estradiol on arginine-vasopressin immunoreactivity is mediated in the supraoptic nucleus by G protein-coupled estrogen receptor 1 and in the paraventricular nucleus by both estrogen receptor β and G protein-coupled estrogen receptor 1. Thus, in contrast to previous studies on the effect of chronic estrogenic treatments, the present findings suggest that estrogen receptor β and G protein-coupled estrogen receptor 1 mediate the acute effects of estradiol on arginine-vasopressin immunoreactivity in the hypothalamus of ovariectomized rats.
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Este es el manuscrito aceptado del artículo. La versión registrada fue publicada por primera vez en Brain Research, Volume 1712, 2019, Pages 93-100, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.brainres.2019.02.002.
This is the accepted manuscript of the article. The copyrighted version was first published in Brain Research, Volume 1712, 2019, Pages 93-100, and is available online at the publisher's website: https://doi.org/10.1016/j.brainres.2019.02.002 .
Categorías UNESCO
Palabras clave
17β-estradiol, GPER, PPT, DPN, G1, Hypothalamus
Citación
Natalia Lagunas, Marilena Marraudino, Miguel de Amorim, Helena Pinos, Paloma Collado, GianCarlo Panzica, Luis M. Garcia-Segura, Daniela Grassi, Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats, Brain Research, Volume 1712, 2019, Pages 93-100, ISSN 0006-8993, https://doi.org/10.1016/j.brainres.2019.02.002
Centro
Facultades y escuelas::Facultad de Psicología
Departamento
Psicobiología