Publicación: 3D-printed Transmembrane Glycoprotein Cancer Biomarker Aptasensor
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Fecha
2021-08-21
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info:eu-repo/semantics/openAccess
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Elsevier
Resumen
Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point-of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics.
Descripción
Este es el manuscrito aceptado del artículo. La versión registrada fue publicada por primera vez en Elsevier, Applied Materials Today, Volume 24, 2021, 101153, ISSN 2352-9407, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.apmt.2021.101153.
This is the accepted manuscript of the article. The Version of Record was first published in Elsevier, Applied Materials Today, Volume 24, 2021, 101153, ISSN 2352-9407, is available online at the publisher's website: https://doi.org/10.1016/j. apmt.2021.101153.
Categorías UNESCO
Palabras clave
Additive manufacturing, Aptamer, Breast cancer cells, Biomarker, Sensor
Citación
Agustín G. Crevillen, Carmen C. Mayorga-Martinez, Jaroslav Zelenka, Silvie Rimpelová, Tomáš Ruml, Martin Pumera, 3D-printed transmembrane glycoprotein cancer biomarker aptasensor, Applied Materials Today, Volume 24, 2021, 101153, ISSN 2352-9407, https://doi.org/10.1016/j.apmt.2021.101153.
Centro
Facultades y escuelas::Facultad de Ciencias
Departamento
Ciencias Analíticas