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Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes

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dc.contributor.authorMartí Centelles, Rosa
dc.contributor.authorFalomir Ventura, Eva
dc.contributor.authorCarda, Miguel
dc.contributor.authorCornago, María del Pilar
dc.contributor.authorClaramunt, Rosa María
dc.contributor.authorNieto Gómez, Carla Isabel
dc.date.accessioned2024-05-20T11:58:28Z
dc.date.available2024-05-20T11:58:28Z
dc.date.issued2016-07
dc.description.abstractA group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.es
dc.description.versionversión final
dc.identifier.doihttp://doi.org/10.1002/ardp.201600067
dc.identifier.issn1521-4184
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12775
dc.journal.issue7
dc.journal.titleArchiv der Pharmazie
dc.journal.volume349
dc.language.isoen
dc.publisherWiley
dc.relation.centerFacultad de Ciencias
dc.relation.departmentQuímica Orgánica y Bio-Orgánica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subject.keywordsCytotoxicity
dc.subject.keywordsCurcuminoid pyrazoles
dc.subject.keywordsGene downregulation
dc.subject.keywordsTelomerase
dc.titleEffects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Geneses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationc6f94a2a-9f54-48f9-a6f1-3115b17b098d
relation.isAuthorOfPublication.latestForDiscoveryc6f94a2a-9f54-48f9-a6f1-3115b17b098d
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