Publicación: Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes
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Fecha
2016-07
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Atribución-NoComercial-SinDerivadas 4.0 Internacional
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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Wiley
Resumen
A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.
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Categorías UNESCO
Palabras clave
Cytotoxicity, Curcuminoid pyrazoles, Gene downregulation, Telomerase
Citación
Centro
Facultad de Ciencias
Departamento
Química Orgánica y Bio-Orgánica