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Intermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthood

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dc.contributor.authorContreras, Ana
dc.contributor.authorPolín Alía, Eduardo
dc.contributor.authorMiguéns, Miguel
dc.contributor.authorPérez García, Carmen
dc.contributor.authorPérez Fernández, Vicente
dc.contributor.authorRuiz Gayo, Mariano
dc.contributor.authorMorales, Lidia
dc.contributor.authorDel Olmo, Nuria
dc.contributor.orcidhttps://orcid.org/0000-0002-2185-0851
dc.contributor.orcidhttps://orcid.org/0000-0002-3292-211X
dc.contributor.orcidhttps://orcid.org/0000-0002-7320-822X
dc.contributor.orcidhttps://orcid.org/0000-0003-4441-0071
dc.date.accessioned2024-11-08T08:47:16Z
dc.date.available2024-11-08T08:47:16Z
dc.date.issued2019-10-15
dc.descriptionThe registered version of this article, first published in “Neuroscience 2019, vol 418", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neuroscience.2019.08.051 La versión registrada de este artículo, publicado por primera vez en “Neuroscience 2019, vol 418", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuroscience.2019.08.051
dc.description.abstractIntermittent and excessive ethanol consumption over very short periods of time, known as binge drinking, is common in the adolescence, considered a vulnerable period to the effects of alcohol in terms of cognitive performance. One of the brain functions most drastically affected by ethanol in adolescent individuals seems to be spatial learning and memory dependent on the hippocampus. In the current study we have focused on the long-lasting effects on spatial learning and memory of intermittent and excessive alcohol consumption compared to chronic and moderate alcohol exposure during adolescence. Five-week old male Wistar rats consumed ethanol for 24 days following two different self-administration protocols that differed in the intake pattern. Spatial learning and memory were evaluated in the radial arm maze. Hippocampal synaptic plasticity was assessed by measuring field excitatory postsynaptic potentials. Hippocampal expression of AMPA and NMDA receptor subunits as well as levels of phosphorylated Ser9-GSK3β (the inactive form of GSK3β) were also quantified. Our results show that both patterns of ethanol intake during adolescence impair spatial learning, memory and cognitive flexibility in the adulthood in a dosedependent way. Nevertheless, changes in synaptic plasticity, gene expression and levels of inactive GSK3β depended on the pattern of ethanol intake.en
dc.description.versionversión final
dc.identifier.citationContreras A, Polín E, Miguéns M, Pérez-García C, Pérez V, Ruiz-Gayo M, Morales L, Del Olmo N. Intermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthood. Neuroscience. 2019 Oct 15;418:205-217. doi: 10.1016/j.neuroscience.2019.08.051
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2019.08.051
dc.identifier.issn0306-4522 | eISSN 1873-7544
dc.identifier.urihttps://hdl.handle.net/20.500.14468/24310
dc.journal.titleNeuroscience
dc.journal.volume418
dc.language.isoen
dc.page.final217
dc.page.initial205
dc.publisherELSEVIER
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicología Básica I
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsGSK3βen
dc.subject.keywordsadolescenceen
dc.subject.keywordsbinge drinkingen
dc.subject.keywordshippocampusen
dc.subject.keywordslong-term depressionen
dc.subject.keywordsmemoryen
dc.titleIntermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthooden
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationa97f4eff-07d2-4c24-908b-adc33b4aa97f
relation.isAuthorOfPublication.latestForDiscoverya97f4eff-07d2-4c24-908b-adc33b4aa97f
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