Publicación: Intermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthood
Cargando...
Fecha
2019-10-15
Editor/a
Director/a
Tutor/a
Coordinador/a
Prologuista
Revisor/a
Ilustrador/a
Derechos de acceso
info:eu-repo/semantics/restrictedAccess
Título de la revista
ISSN de la revista
Título del volumen
Editor
ELSEVIER
Resumen
Intermittent and excessive ethanol consumption over very short periods of time, known as binge drinking, is common in the adolescence, considered a vulnerable period to the effects of alcohol in terms of cognitive performance. One of the brain functions most drastically affected by ethanol in adolescent individuals seems to be spatial learning and memory dependent on the hippocampus. In the current study we have focused on the long-lasting effects on spatial learning and memory of intermittent and excessive alcohol consumption compared to chronic and moderate alcohol exposure during adolescence. Five-week old male Wistar rats consumed ethanol for 24 days following two different self-administration protocols that differed in the intake pattern. Spatial learning and memory were evaluated in the radial arm maze. Hippocampal synaptic plasticity was assessed by measuring field excitatory postsynaptic potentials. Hippocampal expression of AMPA and NMDA receptor subunits as well as levels of phosphorylated Ser9-GSK3β (the inactive form of GSK3β) were also quantified. Our results show that both patterns of ethanol intake during adolescence impair spatial learning, memory and cognitive flexibility in the adulthood in a dosedependent way. Nevertheless, changes in synaptic plasticity, gene expression and levels of inactive GSK3β depended on the pattern of ethanol intake.
Descripción
The registered version of this article, first published in “Neuroscience 2019, vol 418", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neuroscience.2019.08.051
La versión registrada de este artículo, publicado por primera vez en “Neuroscience 2019, vol 418", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuroscience.2019.08.051
Categorías UNESCO
Palabras clave
GSK3β, adolescence, binge drinking, hippocampus, long-term depression, memory
Citación
Contreras A, Polín E, Miguéns M, Pérez-García C, Pérez V, Ruiz-Gayo M, Morales L, Del Olmo N. Intermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthood. Neuroscience. 2019 Oct 15;418:205-217. doi: 10.1016/j.neuroscience.2019.08.051
Centro
Facultades y escuelas::Facultad de Psicología
Departamento
Psicología Básica I