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Electrochemical sensor for the assessment of carbohydrate deficient transferrin: Application to diagnosis of congenital disorders of glycosilation

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dc.contributor.authorTania Sierra
dc.contributor.authorGonzález Crevillén, Agustín
dc.contributor.authorEscarpa Miguel, Jesús Alberto
dc.contributor.orcidhttps://orcid.org/0000-0002-7302-0948
dc.date.accessioned2024-10-07T09:35:35Z
dc.date.available2024-10-07T09:35:35Z
dc.date.issued2021-05
dc.descriptionEste es el manuscrito aceptado del artículo. La versión registrada fue publicada por primera vez por Elsevier en Biosensors and Bioelectronics, Volume 179, 2021, 113098; está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.bios.2021.113098 This is the accepted manuscript of the article. The published version was first published by elsevier in Biosensors and Bioelectronics, Volume 179, 2021, 113098; It is available online at the publisher's website: https://doi.org/10.1016/j.bios.2021.113098
dc.description.abstractCarbohydrate deficient transferrin (CDT) is used as biomarker of different health problems as, for example, congenital disorders of glycosylation (CDG). We propose a screen-printed-based electrochemical sensor for the determination of carbohydrate deficient transferrin using an Os (VI) tag-based electrochemistry. When transferrin is labeled with Os (VI) complex, it generates two voltammetric signals: one from carbohydrates (electrochemical signal of osmium (VI) complex at -0.9 V/Ag) and one from the amino acids present in glycoprotein (intrinsic electrochemical signal of glycoprotein at +0.8 V/Ag). The relationship between the two analytical signals (carbohydrate signal/protein signal) is an indicator of the degree of glycosylation (electrochemical index of glycosylation), which has shown an excellent correlation (r = 0.990) with the official parameter %CDT obtained by CE-UV. The suitability of this approach was demonstrated by analyzing serum samples from CDG patients.en
dc.description.versionversión final
dc.identifier.citationTania Sierra, Agustín G. Crevillen, Alberto Escarpa, Electrochemical sensor for the assessment of carbohydrate deficient transferrin: Application to diagnosis of congenital disorders of glycosilation, Biosensors and Bioelectronics, Volume 179, 2021, 113098, https://doi.org/10.1016/j.bios.2021.113098
dc.identifier.doihttps://doi.org/10.1016/j.bios.2021.113098
dc.identifier.issn0956-5663
dc.identifier.urihttps://hdl.handle.net/20.500.14468/23933
dc.journal.titleBiosensors and Bioelectronics
dc.journal.volume179
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Ciencias
dc.relation.departmentCiencias Analíticas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject24 Ciencias de la Vida
dc.subject.keywordsCarbohydrate deficient transferrinen
dc.subject.keywordsCongenital disorders of glycosylationen
dc.subject.keywordsScreen printed carbon electrodeen
dc.subject.keywordsElectrochemical tag Rare diseaseen
dc.titleElectrochemical sensor for the assessment of carbohydrate deficient transferrin: Application to diagnosis of congenital disorders of glycosilationen
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dc.typejournal articleen
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relation.isAuthorOfPublication.latestForDiscovery0f39284a-d95a-443a-bb2e-21297ec40b76
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