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Intergenerational Patterns of DNA Methylation in Procambarus clarkii Following Exposure to Genotoxicants: A Conjugation in Past Simple or Past Continuous?

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dc.contributor.authorMarçal, Raquel
dc.contributor.authorLlorente Ortega, Lola
dc.contributor.authorHerrero Felipe, Óscar
dc.contributor.authorPlanello Carro, María del Rosario
dc.contributor.authorGuilherme, Sofia
dc.contributor.authorPacheco, Mário
dc.contributor.orcidhttps://orcid.org/0000-0002-1716-6889
dc.date.accessioned2025-01-28T09:29:55Z
dc.date.available2025-01-28T09:29:55Z
dc.date.issued2021
dc.descriptionThe registered version of this article, first published in “Toxics, vol. 9, 2021", is available online at the publisher's website: MDPI, https://doi.org/10.3390/toxics9110271 La versión registrada de este artículo, publicado por primera vez en “Toxics, vol. 9, 2021", está disponible en línea en el sitio web del editor: MDPI, https://doi.org/10.3390/toxics9110271
dc.description.abstractEpigenome is susceptible to modulation by environmental pressures—namely, through alterations in global DNA methylation, impacting the organism condition and, ultimately, reverberating on the phenotype of the subsequent generations. Hence, an intergenerational study was conducted, aiming to clarify the influence of genotoxicants on global DNA methylation of the crayfish Procambarus clarkii. Two subsequent generations were exposed to the herbicide penoxsulam (Px; 23 µg·L−1) and to the genotoxicant model ethyl methanesulfonate (EMS; 5 mg·L−1). Px did not induce changes in DNA methylation of adult crayfish (F0). However, the hypomethylation occurring in unexposed F1 juveniles demonstrated that the history of exposure per se can modulate epigenome. In F1 descendants of the Px-exposed group, methylome (hypermethylated) was more affected in males than in females. EMS-induced hypomethylation in adult females (F0), also showed gender specificity. In addition, hypomethylation was also observed in the unexposed F1 crayfish, indicating an intergenerational epigenetic effect. The modulatory role of past exposure to penoxsulam or to EMS also showed a dependency on the crayfish developmental stage. Overall, this research revealed that indirect experiences (events occurring in a predecessor generation) can have an impact even greater than direct experiences (present events) on the epigenetic dynamics.en
dc.description.versionversión publicada
dc.identifier.citationMarçal, R., Llorente, L., Herrero, O., Planelló, R., Guilherme, S., & Pacheco, M. (2021). Intergenerational Patterns of DNA Methylation in Procambarus clarkii Following Exposure to Genotoxicants: A Conjugation in Past Simple or Past Continuous? Toxics, 9(11), 271. https://doi.org/10.3390/toxics9110271
dc.identifier.doihttps://doi.org/10.3390/toxics9110271
dc.identifier.issn2305-6304
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25572
dc.journal.issue11
dc.journal.titleToxics
dc.journal.volume9
dc.language.isoen
dc.page.initial271
dc.publisherMDPI
dc.relation.centerFacultades y escuelas::Facultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.keywordscrustaceanen
dc.subject.keywordsepigeneticsen
dc.subject.keywordsmethylomeen
dc.subject.keywordsintergenerationalen
dc.subject.keywordsgenotoxicen
dc.subject.keywordspesticidesen
dc.subject.keywordspenoxsulamen
dc.subject.keywordsepigenotoxicologyen
dc.titleIntergenerational Patterns of DNA Methylation in Procambarus clarkii Following Exposure to Genotoxicants: A Conjugation in Past Simple or Past Continuous?en
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublication16da09a8-34db-4259-90d7-36928325faff
relation.isAuthorOfPublication1de7b6f9-dd97-4518-8f0e-3c54768bfe6a
relation.isAuthorOfPublication.latestForDiscovery16da09a8-34db-4259-90d7-36928325faff
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