Persona:
Zamora Crespo, Berta

Cargando...
Foto de perfil
Dirección de correo electrónico
ORCID
Fecha de nacimiento
Proyectos de investigación
Unidades organizativas
Puesto de trabajo
Apellidos
Zamora Crespo
Nombre de pila
Berta
Nombre

Resultados de la búsqueda

Mostrando 1 - 1 de 1
  • Publicación
    Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats
    (Elsevier, 2019-03-29) Pereda Pérez, Inmaculada; Valencia Jiménez, Azucena; Baliyan, Shishir; Núñez, Ángel; Sanz García, Ancor; Rodríguez Fernández, Raquel; Esteban, José Antonio; Venero Núñez, César; Zamora Crespo, Berta; Elsevier; https://orcid.org/0000-0002-8013-4812; https://orcid.org/0000-0002-5024-5108
    Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.