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Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats

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dc.contributor.authorFernández García, José Manuel
dc.contributor.authorTezanos, Patricia
dc.contributor.authorPino Osuna, María José
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorCollado Guirao, Paloma
dc.date.accessioned2024-05-20T11:52:36Z
dc.date.available2024-05-20T11:52:36Z
dc.date.issued2023
dc.description.abstractIn the present work we analyzed the effects of postnatal exposure to two doses of genistein (10 μg/g or 50 μg/g) from postnatal (P) day 6 to P13, on the morphology of the arcuate nucleus (Arc). The analyses of Arc coronal brain sections at 90 days showed that the ArcMP had higher values in volume, Nissl-stained neurons and GPER-ir neurons in males than in females and the treatment with genistein abolished these sex differences in most of the parameters studied. Moreover, in males, but not in females, the GPER-ir neurons decreased in the ArcMP but increased in the ArcL with both doses of genistein. In the ArcLP, GPER-ir population increased with the lowest doses and decreased with the highest one in males. Our results confirm that the Arc subdivisions have differential vulnerability to the effects of genistein during development, depending on which neuromorphological parameters, dose and sex are analyzed.en
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.1016/j.mce.2023.111933
dc.identifier.issn0303-7207
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12662
dc.journal.titleMolecular and Cellular Endocrinology
dc.journal.volume570
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleGenistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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