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Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.

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dc.contributor.authorCasquero Veiga, M.
dc.contributor.authorFernández, J.
dc.contributor.authorLamanna Rama, N.
dc.contributor.authorGómez Rangel, Vanessa
dc.contributor.authorGálvez Robleño, Carlos
dc.contributor.authorVillar, C. J.
dc.contributor.authorLombó, F.
dc.contributor.authorAbalo, R.
dc.contributor.authorDesco, Manuel
dc.contributor.authorSoto Montenegro, M. L.
dc.contributor.authorRomero Hortelano, Miguel
dc.contributor.authorSanta Marta Pastrana, Cristina María
dc.date.accessioned2024-05-20T11:28:49Z
dc.date.available2024-05-20T11:28:49Z
dc.date.issued2023-04-20
dc.description.abstractThe microbiota-gut-brain axis is a complex interconnected system altered in schizophrenia. The antioxidant N-acetylcysteine (NAC) has been proposed as an adjunctive therapy to antipsychotics in clinical trials, but its role in the microbiota-gut-brain axis has not been sufficiently explored. We aimed to describe the effect of NAC administration during pregnancy on the gut-brain axis in the offspring from the maternal immune stimulation (MIS) animal model of schizophrenia. Pregnant Wistar rats were treated with PolyI:C/Saline. Six groups of animals were studied according to the study factors: phenotype (Saline, MIS) and treatment (no NAC, NAC 7 days, NAC 21 days). Offspring were subjected to the novel object recognition test and were scanned using MRI. Caecum contents were used for metagenomics 16S rRNA sequencing. NAC treatment prevented hippocampal volume reduction and long-term memory deficits in MIS-offspring. In addition, MIS-animals showed lower bacterial richness, which was prevented by NAC. Moreover, NAC7/NAC21 treatments resulted in a reduction of proinflammatory taxons in MIS-animals and an increase in taxa known to produce anti-inflammatory metabolites. Early approaches, like this one, with anti-inflammatory/anti-oxidative compounds, especially in neurodevelopmental disorders with an inflammatory/oxidative basis, may be useful in modulating bacterial microbiota, hippocampal size, as well as hippocampal-based memory impairments.en
dc.description.versionversión publicada
dc.identifier.doihttp://doi.org/10.3390/ANTIOX12040970
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12075
dc.journal.issue4
dc.journal.titleAntioxidants
dc.journal.volume12
dc.language.isoen
dc.publisherMDPI
dc.relation.centerFacultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.keywordsPoly I:C
dc.subject.keywordsschizophrenia
dc.subject.keywordsmicrobiota-gut-brain axis
dc.subject.keywordsinflammation
dc.subject.keywordsoxidative stress
dc.titleMaternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.es
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication680ca446-ab0c-4f58-89bb-d2b3c88b12fe
relation.isAuthorOfPublication3d74eb47-9db3-41ef-83e7-f7bdb91dde8c
relation.isAuthorOfPublication.latestForDiscovery680ca446-ab0c-4f58-89bb-d2b3c88b12fe
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