Publicación:
Skewness-Kurtosis Model-Based Projection Pursuit with Application to Summarizing Gene Expression Data

Vista sencilla de ítem
dc.contributor.authorMartín Arevalillo, Jorge
dc.contributor.authorNavarro Veguillas, Hilario
dc.date.accessioned2024-05-20T11:24:52Z
dc.date.available2024-05-20T11:24:52Z
dc.date.issued2022-04-24
dc.description.abstractNon-normality is a usual fact when dealing with gene expression data. Thus, flexible models are needed in order to account for the underlying asymmetry and heavy tails of multivariate gene expression measures. This paper addresses the issue by exploring the projection pursuit problem under a flexible framework where the underlying model is assumed to follow a multivariate skew-t distribution. Under this assumption, projection pursuit with skewness and kurtosis indices is addressed as a natural approach for data reduction. The work examines its properties giving some theoretical insights and delving into the computational side in regards to the application to real gene expression data. The results of the theory are illustrated by means of a simulation study; the outputs of the simulation are used in combination with the theoretical insights to shed light on the usefulness of skewness-kurtosis projection pursuit for summarizing multivariate gene expression data. The application to gene expression measures of patients diagnosed with triple-negative breast cancer gives promising findings that may contribute to explain the heterogeneity of this type of tumors.en
dc.description.versionversión publicada
dc.identifier.doihttp://doi.org/10.3390/math9090954
dc.identifier.issn2227-7390
dc.identifier.urihttps://hdl.handle.net/20.500.14468/11930
dc.journal.issue9
dc.journal.titleMathematics
dc.journal.volume9
dc.language.isoen
dc.publisherMDPI
dc.relation.centerFacultad de Ciencias
dc.relation.departmentEstadística, Investigación Operativa y Cálculo Numérico
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subject.keywordsskewness
dc.subject.keywordskurtosis
dc.subject.keywordsskew-t distribution
dc.subject.keywordsprojection pursuit
dc.subject.keywordsgene expression data
dc.titleSkewness-Kurtosis Model-Based Projection Pursuit with Application to Summarizing Gene Expression Dataes
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationea1c092a-eceb-49c8-abb7-d4d52f53930a
relation.isAuthorOfPublicationb4ef2ce4-140a-4dfd-b87f-363a7a9136e5
relation.isAuthorOfPublication.latestForDiscoveryea1c092a-eceb-49c8-abb7-d4d52f53930a
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Navarro_Veguillas_Hilario_Skewness_kurtosis.pdf
Tamaño:
1.35 MB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos y papers