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Development of a molecularly imprinted polymeric membrane for determination of macrolide antibiotics from cow milk

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dc.contributor.authorCañadas Soler, Raquel
dc.contributor.authorPaniagua González, Gema
dc.contributor.authorFernández Hernando, Pilar
dc.contributor.authorGarcinuño Martínez, Rosa Mª
dc.date.accessioned2024-05-20T11:18:04Z
dc.date.available2024-05-20T11:18:04Z
dc.date.issued2022-05-17
dc.description.abstractA molecular imprinted membrane (MIM) was prepared for the selective binding of macrolide antibiotics by UV-initiated non-covalent imprinting approach . The membrane was modified by a UV - photographting technique in the presence of molecule templates of erythromycin (ERY) and spiramycin (SPI) with methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinker. The nanofunctionalized MIM obtained was characterized by a morphological study using scanning electron microscopy (SEM), as well as by a study of its adsorption capacity by online solid phase extraction (SPE) procedure. Variables affecting the MIM-SPE method were optimized to maximize the extraction of macrolide antibiotics of interest and a high-performance liquid chromatography (HPLC) method was used for the analysis. Good linearity and precision were obtained for ERY and SPI, with average recoveries up to 86.14 % and 34.73 %, respectively, with a relative standard deviation (RSD) lower than 6 %. In addition, selectivity was studied for other macrolides with similar structure to the templates, such as roxithromycin (ROX), josamycin (JOS), ivermectin (IVER) and tylosin (TYL). The proposed MIM-SPE-HPLC methodology was effectively applied to ERY and SPI determination in commercial doped semi-skimmed cow’s milk samples.en
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.1016/j.polymer.2022.124843
dc.identifier.issn0032-3861 - eISSN: 1873-2291
dc.identifier.urihttps://hdl.handle.net/20.500.14468/11586
dc.journal.titlePolymer
dc.journal.volume249
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Ciencias
dc.relation.departmentCiencias Analíticas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsMolecularly imprinted membrane
dc.subject.keywordsMacrolide antibiotics
dc.subject.keywordsCow milk
dc.titleDevelopment of a molecularly imprinted polymeric membrane for determination of macrolide antibiotics from cow milkes
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery6e5a84b2-e6a7-4bb1-9bdc-4e9831d90d11
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