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Prenatal Low-Protein and Low-Calorie Diets Differentially Alter Arcuate Nucleus Morphology in Newborn Male Rats

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dc.contributor.authorBlanco, Noemí
dc.contributor.authorFernández García, José Manuel
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorBallesta, Antonio
dc.contributor.authorGarcía Úbeda, Rocío
dc.contributor.authorCollado Guirao, Paloma
dc.contributor.authorPinos, Helena
dc.date.accessioned2024-12-27T13:54:23Z
dc.date.available2024-12-27T13:54:23Z
dc.date.issued2022-06
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Front. Neuroanat. 16:896732, está disponible en línea en el sitio web del editor: https://doi.org/10.3389/fnana.2022.896732. The copyrighted version of this article, first published in Front. Neuroanat. 16:896732, is available online at the publisher's website: https://doi.org/10.3389/fnana.2022.896732
dc.description.abstractBackground: Malnutrition during the early stages of development produces alterations that can compromise the functioning of the hypothalamic circuits that regulate food intake. The purpose of this study is to analyze the effects that a low-protein and low-calorie diet has on the morphology of the arcuate nucleus (ARC) of the hypothalamus in newborn male and female rats. Methods: On gestational day 6 (G6), six pregnant rats were divided into two groups. One group was made up of three pregnant rats, which were fed ad libitum with a control diet (20% casein), and the other one was made up of three pregnant rats, which were fed ad libitum with a low-protein diet (8% casein) and 30% of a calorie-restricted diet. On the day of birth, pups were sacrificed, resulting in four experimental groups: control male, control female, low-protein and low-calorie diet male, and low-protein and low-calorie diet female (n = 5 in each group). The volume and number of neurons, together with the neuronal density and number of apoptotic cells, were measured. Results: Males on a low-protein and low-calorie diet showed a significant increase in the number of neurons and in the neuronal density of the ARC with regard to the rest of the groups studied. These increases were also reflected in the posterior part of the nucleus. Although the existence of sexual dimorphism was not detected in any of the parameters studied in the control groups, the number of neurons and neuronal density showed differences between males and females fed with a low-protein and low-calorie diets due to the increase in the number of neurons shown by the male. No significant differences were found in the number of apoptotic cells. Conclusion: Our results show that a low-protein and low-calorie diet during the prenatal stage produces alterations in the ARC of the hypothalamus in newborn animals and, more importantly, that the effects of malnutrition are evident in males but not in females. Therefore, it is essential to follow a balanced diet during the early stages of life to ensure optimal development of the neural circuits that regulate eating.en
dc.description.versionversión publicada
dc.identifier.citationBlanco N, Fernández-García JM, Carrillo B, Ballesta A, García-Úbeda R, Collado P and Pinos H (2022) Prenatal Low-Protein and Low-Calorie Diets Differentially Alter Arcuate Nucleus Morphology in Newborn Male Rats. Front. Neuroanat. 16:896732. https://doi.org/10.3389/fnana.2022.896732
dc.identifier.doihttps://doi.org/10.3389/fnana.2022.896732
dc.identifier.issn1662-5129
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25063
dc.journal.titleFrontiers in Neuroanatomy
dc.journal.volume16
dc.language.isoen
dc.publisherFrontiers Media
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsLow-protein and caloric dieten
dc.subject.keywordsgestational exposureen
dc.subject.keywordsarcuate nucleus (ARC)en
dc.subject.keywordshypothalamusen
dc.subject.keywordssex differencesen
dc.titlePrenatal Low-Protein and Low-Calorie Diets Differentially Alter Arcuate Nucleus Morphology in Newborn Male Ratsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryf6f9a9e6-3e33-4985-b829-a5695cfd56dc
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