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An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

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dc.contributor.authorBorrego Ruiz, Alejandro
dc.contributor.authorBorrego García, Juan José
dc.date.accessioned2024-09-19T09:54:46Z
dc.date.available2024-09-19T09:54:46Z
dc.date.issued2024-01
dc.description.abstractThere is a lot of evidence establishing that nervous system development is related to the composition and functions of the gut microbiome. In addition, the central nervous system (CNS) controls the imbalance of the intestinal microbiota, constituting a bidirectional communication network. At present, various gut-brain crosstalk routes have been described, including immune, endocrine and neural circuits via the vagal pathway. Several empirical data have associated gut microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism and Parkinson's disease, and with other psychological disorders, like anxiety and depression. Fecal microbiota transplantation (FMT) therapy has shown that the gut microbiota can transfer behavioral features to recipient animals, which provides strong evidence to establish a cause-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, have demonstrated an important influence of microbiota on neurological disorders by the synthesis of neuroactive compounds that interact with the nervous system and by the regulation of inflammatory and endocrine processes. Further research is needed to demonstrate the influence of gut microbiota dysbiosis on psychiatric and psychological disorders, and how microbiota-based interventions may be used as potential therapeutic tools.en
dc.description.versionversión publicada
dc.identifier.citationBorrego-Ruiz, A., & Borrego, J. J. (2024). An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 128, 110861. https://doi.org/10.1016/j.pnpbp.2023.110861
dc.identifier.doihttps://doi.org/10.1016/j.pnpbp.2023.110861
dc.identifier.issn0278-5846; e-ISSN: 878-4216
dc.identifier.urihttps://hdl.handle.net/20.500.14468/23800
dc.journal.titleProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.journal.volume128
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicología Social y de las Organizaciones
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject24 Ciencias de la Vida::2490 Neurociencias
dc.subject.keywordsHuman microbiomeen
dc.subject.keywordsGut microbiotaen
dc.subject.keywordsDysbiosisen
dc.subject.keywordsNeuropsychiatric diseasesen
dc.subject.keywordsPsychological disordersen
dc.subject.keywordsGut microbiota-CNS axisen
dc.titleAn updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disordersen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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