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Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice

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dc.contributor.authorFernández Felipe, J.
dc.contributor.authorMerino, B.
dc.contributor.authorSanz Martos, Ana Belén
dc.contributor.authorPlaza, A.
dc.contributor.authorContreras, A.
dc.contributor.authorNaranjo, V.
dc.contributor.authorMorales, L
dc.contributor.authorChowen, J. A.
dc.contributor.authorCano, V.
dc.contributor.authorRuiz Gayo, M.
dc.contributor.authorOlmo Izquierdo, Nuria Del
dc.date.accessioned2024-10-14T16:54:53Z
dc.date.available2024-10-14T16:54:53Z
dc.date.issued2021-10-05
dc.descriptionThe registered version of this article, first published in Psychoneuroendocrinology, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.psyneuen.2021.105429
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Psychoneuroendocrinology, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.psyneuen.2021.105429
dc.description.abstractConsumption of high-fat diets (HFD) has been associated with neuronal plasticity deficits and cognitive disorders linked to the alteration of glutamatergic disorders in the hippocampus. As young individuals are especially vulnerable to the effects of nutrients and xenobiotics on cognition, we studied the effect of chronic consumption of saturated (SOLF) and unsaturated oil-enriched foods (UOLF) on: i) spatial memory; ii) hippocampal synaptic transmission and plasticity; and iii) gene expression of glutamatergic receptors and hormone receptors in the hippocampus of adolescent and adult mice. Our results show that both SOLF and UOLF impair spatial short-term memory. Accordingly, hippocampal synaptic plasticity mechanisms underlying memory, and gene expression of NMDA receptor subunits are modulated by both diets. On the other hand, PPARγ gene expression is specifically down-regulated in adolescent SOLF individuals and up-regulated in adult UOLF mice.en
dc.description.versionversión publicada
dc.identifier.citationFernández-Felipe, Merino, Sanz-Martos, Plaza, Contreras, Naranjo, Morales, Chowen, Cano, Ruiz-Gayo, & Del Olmo. (2021). Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice. Psychoneuroendocrinology, 133. https://doi.org/10.1016/J.PSYNEUEN.2021.105429
dc.identifier.doihttps://doi.org/10.1016/j.psyneuen.2021.105429
dc.identifier.issn1873-3360
dc.identifier.urihttps://hdl.handle.net/20.500.14468/24051
dc.journal.titlePsychoneuroendocrinology
dc.journal.volume133
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject61 Psicología
dc.subject24 Ciencias de la Vida
dc.subject.keywordsSOLFen
dc.subject.keywordsUOLFes
dc.subject.keywordsLTPes
dc.subject.keywordsLTDes
dc.subject.keywordssynaptic plasticityes
dc.subject.keywordsmemoryes
dc.titleSaturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent miceen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublication1311c3b1-eace-442e-bb19-5b2328963a42
relation.isAuthorOfPublication.latestForDiscovery1311c3b1-eace-442e-bb19-5b2328963a42
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