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Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo

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dc.contributor.authorTorres Ruiz, Mónica
dc.contributor.authorAlba González, Mercedes de
dc.contributor.authorGonzález, M. Carmen
dc.contributor.authorCañas Portilla, Ana Isabel
dc.contributor.authorVieja, Antonio de la
dc.contributor.authorMorales Camarzana, Consolación Mónica
dc.contributor.authorMartín Folgar, Raquel
dc.date.accessioned2024-05-20T11:28:43Z
dc.date.available2024-05-20T11:28:43Z
dc.date.issued2023-05-20
dc.description.abstractNanoplastics (NP) are present in aquatic and terrestrial ecosystems. Humans can be exposed to them through contaminated water, food, air, or personal care products. Mechanisms of NP toxicity are largely unknown and the Zebrafish embryo poses an ideal model to investigate them due to its high homology with humans. Our objective in the present study was to combine a battery of behavioral assays with the study of endocrine related gene expression, to further explore potential NP neurotoxic effects on animal behavior. Polystyrene nanoplastics (PSNP) were used to evaluate NP toxicity. Our neurobehavioral profiles include a tail coiling assay, a light/dark activity assay, two thigmotaxis anxiety assays (auditory and visual stimuli), and a startle response - habituation assay in response to auditory stimuli. Results show PSNP accumulated in eyes, neuromasts, brain, and digestive system organs. PSNP inhibited acetylcholinesterase and altered endocrine-related gene expression profiles both in the thyroid and glucocorticoid axes. At the whole organismlevel, we observed altered behaviors such as increased activity and anxiety at lower doses and lethargy at a higher dose, which could be due to a variety of complex mechanisms ranging from sensory organ and central nervous system effects to others such as hormonal imbalances. In addition, we present a hypothetical adverse outcome pathway related to these effects. In conclusion, this study provides new understanding into NP toxic effects on zebrafish embryo, emphasizing a critical role of endocrine disruption in observed neurotoxic behavioral effects, and improving our understanding of their potential health risks to human populations.en
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.1016/j.scitotenv.2023.162406
dc.identifier.issn0048-9697; e-ISSN: 1879-1026
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12072
dc.journal.titleScience of The Total Environment
dc.journal.volume874
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.keywordsNanomaterial
dc.subject.keywordsPlastic
dc.subject.keywordsDevelopment
dc.subject.keywordsToxicity
dc.subject.keywordsBehavior
dc.subject.keywordsHormones
dc.titleNeurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryoes
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication700f9417-c7b6-45f0-a781-3b1b8ae73b9c
relation.isAuthorOfPublicationaa546ae3-0398-4b31-a9c4-da2f3ff2b802
relation.isAuthorOfPublication.latestForDiscovery700f9417-c7b6-45f0-a781-3b1b8ae73b9c
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