Microbial involvement in myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology

Borrego Ruiz, Alejandro; Borrego, Juan J.

Publicación:
Microbial involvement in myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology

dc.contributor.author	Borrego Ruiz, Alejandro
dc.contributor.author	Borrego, Juan J.
dc.date.accessioned	2025-06-18T08:28:28Z
dc.date.available	2025-06-18T08:28:28Z
dc.date.issued	2024-12-02
dc.description	The registered version of this article, first published in “Microbes & Immunity, 2, 2025", is available online at the publisher's website: Accscience Publishing, https://doi.org/10.36922/mi.4783 La versión registrada de este artículo, publicado por primera vez en “Microbes & Immunity, 2, 2025", está disponible en línea en el sitio web del editor: Accscience Publishing, https://doi.org/10.36922/mi.4783
dc.description.abstract	Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and disabling disease related to persistent fatigue, exercise intolerance, post-exertional malaise, cognitive dysfunction, and musculoskeletal/joint pain. Gastrointestinal comorbidities, including irritable bowel syndrome, have been reported in affected individuals, indicating a potential role of gut microbiota in disease progression. In this paper, bacterial and metabolomic dysbiosis in subjects with ME/CFS are reviewed, and phenotypic, microbial, and metabolic biomarkers specific to individual cohorts are also identified. Furthermore, microbiome fluctuations or metabolic endotoxemia are proposed as possible disorder biomarkers. Based on the fact that gut microbiota dysbiosis reverts to a state of eubiosis in long-term patients with this condition, it may be hypothesized that disease progression begins with the loss of beneficial gut microorganisms, particularly short-chain fatty acid producers, leading to more widespread gastrointestinal phenotypes that are subsequently reflected in plasma metabolite levels. These alterations, specific of each individual, thereby result in metabolic and phenotypic shifts and in ME/CFS.	en
dc.description.version	versión publicada
dc.identifier.citation	Borrego-Ruiz, A., & Borrego, J. J. (2025). Microbial involvement in myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology. Microbes & Immunity, 2(1), 17–26. https://doi.org/10.36922/mi.4783
dc.identifier.doi	https://doi.org/10.36922/mi.4783
dc.identifier.issn	3041-0886, e ISSN: 3029-2883
dc.identifier.uri	https://hdl.handle.net/20.500.14468/26895
dc.journal.issue	1
dc.journal.title	Microbes & Immunity
dc.journal.volume	2
dc.language.iso	en
dc.page.final	26
dc.page.initial	17
dc.publisher	AccScience Publishing
dc.relation.center	Facultades y escuelas::Facultad de Psicología
dc.relation.department	PSICOLOGÍA SOCIAL Y DE LAS ORGANIZACIONES
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.license	Atribución 4.0 Internacional
dc.subject.keywords	myalgic encephalomyelitis/chronic fatigue syndrome	en
dc.subject.keywords	post-exertional malaise	en
dc.subject.keywords	gut microbiota	en
dc.subject.keywords	metabolic biomarkers	en
dc.subject.keywords	pathophysiological phenotypes	en
dc.title	Microbial involvement in myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology	en
dc.type	artículo	es
dc.type	journal article	en
dspace.entity.type	Publication
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relation.isAuthorOfPublication.latestForDiscovery	4056d333-e1b2-4759-8b5a-af6f4e202fd8