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Relationship between autism spectrum disorder and pesticides: A systematic review of human and preclinical models

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dc.contributor.authorBiosca Brull, Judit
dc.contributor.authorPérez Fernández, Cristian
dc.contributor.authorMora, Santiago
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorPinos Sánchez, María Elena
dc.contributor.authorMaria Conejo, Nelida
dc.contributor.authorCollado Guirao, Paloma
dc.contributor.authorArias, Jorge L.
dc.contributor.authorMartín Sánchez, Fernando
dc.contributor.authorSánchez Santed, Fernando
dc.contributor.authorColomina, Maria Teresa
dc.date.accessioned2024-12-30T07:32:46Z
dc.date.available2024-12-30T07:32:46Z
dc.date.issued2021-05-03
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en International Journal of Environmental Research and Public Health. 2021; 18(10):5190, está disponible en línea en el sitio web del editor: https://doi.org/10.3390/ijerph18105190. The copyrighted version of this article, first published in the International Journal of Environmental Research and Public Health. 2021; 18(10):5190, is available online at the publisher's website: https://doi.org/10.3390/ijerph18105190.
dc.description.abstractAutism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.en
dc.description.versionversión publicada
dc.identifier.citationBiosca-Brull J, Pérez-Fernández C, Mora S, Carrillo B, Pinos H, Conejo NM, Collado P, Arias JL, Martín-Sánchez F, Sánchez-Santed F, et al. Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models. International Journal of Environmental Research and Public Health. 2021; 18(10):5190. https://doi.org/10.3390/ijerph18105190
dc.identifier.doihttps://doi.org/10.3390/ijerph18105190
dc.identifier.issn1660-4601
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25065
dc.journal.issue10
dc.journal.titleInternational Journal of Environmental Research and Public Health
dc.journal.volume18
dc.language.isoen
dc.publisherMDPI
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsautism spectrum disorderen
dc.subject.keywordssociabilityen
dc.subject.keywordspesticideen
dc.subject.keywordsorganophosphateen
dc.subject.keywordscarbamatesen
dc.subject.keywordsorganochlorineen
dc.subject.keywordschlorpyrifosen
dc.titleRelationship between autism spectrum disorder and pesticides: A systematic review of human and preclinical modelsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublication71657c77-6882-40f7-a5c9-03b3da3a0f26
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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