Publicación:
Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)

Vista sencilla de ítem
dc.contributor.authorTorres Ruiz, Mónica
dc.contributor.authorAlba, Mercedes de
dc.contributor.authorCañas Portilla, Ana Isabel
dc.contributor.authorGonzález, M. Carmen
dc.contributor.authorMorales Camarzana, Consolación Mónica
dc.contributor.authorMartín Folgar, Raquel
dc.date.accessioned2024-05-20T11:28:27Z
dc.date.available2024-05-20T11:28:27Z
dc.date.issued2022-11-02
dc.description.abstractPlastics pose a health hazard to living beings and the environment. Plastic degradation produces nano-sized plastic particles (NPs) that end up in terrestrial and aquatic ecosystems, including oceans, rivers, and lakes. Their presence in air, drinking water, sediments, food, and personal care products leads to a variety of exposure routes for living beings, including humans. The toxicity mechanisms of these nanomaterials (NMs) in living organisms and ecosystems are currently unknown, making it a priority to understand their effects at the molecular and cellular levels. The zebrafish (Zf) (Danio rerio) is a model organism which has a high homology with humans and has been widely used to assess the hazard of different xenobiotics. In this study, the expression changes of different genes in 120 hpf Zf embryos (Zfe) after exposure to polystyrene (PS) NPs (30 nm) at concentrations of 0.1, 0.5 and 3 ppm were investigated. The results showed that the gene encoding heat shock protein (hsp70) was down-regulated in a dose-dependent manner. The genes encoding superoxide dismutase (SOD 1 and SOD 2), apoptotic genes (cas 1 and cas 8) and interleukin 1-β (il1β) were activated at the concentration of 3 ppm PS NP, while the anti-apoptotic gene Bcl2α was inhibited at 0.5 and 3 ppm. In addition, the neurotransmitter-related gene Acetyl-Cholinesterase (ache) was significantly inhibited and the DNA repair genes (gadd45α and rad51) were also down-regulated. In contrast, the mitochondrial metabolism-related gene cox1 did not alter its expression in any of the treatments. Most of the changes in gene expression occurred at the highest concentration of NPs. Overall, the results indicated that NPs generated cellular stress that caused certain alterations in normal gene expression (oxidative stress, apoptotic and inflammatory processes, neurotoxicity and anti-apoptotic proteins), but did not cause any mortality after 120 hpf exposure at the three concentrations assayed. These results highlight the need for further studies investigating the effects, at the molecular level, of these materials in humans and other living organisms.en
dc.description.versionversión final
dc.identifier.doihttps://doi.org/10.1016/j.chemosphere.2022.137077
dc.identifier.issn0045-6535
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12063
dc.journal.issue1
dc.journal.titleChemosphere
dc.journal.volume312
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.titleMolecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)es
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication700f9417-c7b6-45f0-a781-3b1b8ae73b9c
relation.isAuthorOfPublicationaa546ae3-0398-4b31-a9c4-da2f3ff2b802
relation.isAuthorOfPublication.latestForDiscovery700f9417-c7b6-45f0-a781-3b1b8ae73b9c
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Morales Camarzana_Monica_Molecular effects of polystyre.pdf
Tamaño:
4.85 MB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos y papers