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Socialization, and its modulation by sex, on the development and recovery of activity-based anorexia in rats

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dc.contributor.authorMartínez Herrada, Antonio
dc.contributor.authorPaz Regidor, Ana María de
dc.contributor.authorPellón Suárez de Puga, Ricardo
dc.date.accessioned2024-05-20T11:53:23Z
dc.date.available2024-05-20T11:53:23Z
dc.date.issued2023-07-17
dc.description.abstractThe activity-based anorexia (ABA) animal model has been used in the laboratory to study the role of excessive physical activity in the manifestation of anorexia nervosa (AN) in humans. Factors of social context are crucial in human health and the emergence of many psychological disorders, which have also been observed in studies using different mammal species that, like human beings, set their lives in groups. In the present study, the animals’ social condition was manipulated to observe the effect of socialization in ABA development, and the possible different influence of the variable sex on the phenomenon. Eighty Wistar Han rats were distributed into four male and four female groups with 10 subjects each, manipulating social conditions (group housing or social isolation) and physical activity (access or not to a running wheel). Throughout the procedure, all groups had food restricted to 1 h/day during the light period. Furthermore, ABA experimental groups with access to the running wheel had two periods of access to the wheel of 2 h each, one before and the other after the food period. In this experiment, socialized rats were less vulnerable to weight loss during the procedure, although there were no differences between the ABA groups. Moreover, social enrichment was shown to be an enabling variable of the animals’ recovery after their withdrawal from the procedure, with this effect being more pronounced in females. The results in this study suggest the need to further in the analysis of the role of socialization in the development of ABA.en
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.1016/j.physbeh.2023.114271
dc.identifier.issn0031-9384 - eISSN: 1873-507X
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12677
dc.journal.titlePhysiology and Behavior
dc.journal.volume270
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicología Básica I
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsAnorexia nervosa
dc.subject.keywordsActivity-based anorexia
dc.subject.keywordsSocialization
dc.subject.keywordsExcessive activity
dc.subject.keywordsSex differences
dc.subject.keywordsRecovery
dc.subject.keywordsRats
dc.titleSocialization, and its modulation by sex, on the development and recovery of activity-based anorexia in ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication080d4686-838a-418c-9765-533f5ccf4dcd
relation.isAuthorOfPublicationcd014de7-025a-4bfa-8621-c28b6d8821d6
relation.isAuthorOfPublication8edbde84-9307-47aa-9ef8-5e85de175df6
relation.isAuthorOfPublication.latestForDiscovery080d4686-838a-418c-9765-533f5ccf4dcd
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