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Environmentally Relevant Concentrations of the Insecticide Fipronil Modulated Molecular Response in Chironomus riparius

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dc.contributor.authorda Silva Pinto, Thandy Junio
dc.contributor.authorMartínez Guitarte, José Luis
dc.contributor.authorDias, Mariana Amaral
dc.contributor.authorMontagner, Cassiana Carolina
dc.contributor.authorGaeta Espindola, Evaldo Luiz
dc.contributor.authorMuñiz González, Ana Belén
dc.date.accessioned2024-10-11T08:55:41Z
dc.date.available2024-10-11T08:55:41Z
dc.date.issued2023-11-29
dc.description.abstractPesticides employed worldwide for crop protection easily reach aquatic systems, which act as the main reservoirs, and become a risk factor for aquatic fauna. Fipronil is a broad‐spectrum insecticide acting on the insect nervous system; however, other effects and systems unrelated to this mechanism could be affected in non‐target organisms. Thus, the present study aimed to assess the impact of fipronil on the suborganismal response (gene expression and enzymatic activity) of Chironomus riparius larvae as a model organism in ecotoxicology. To this end, short‐term toxicity tests were carried out with fourth‐instar larvae exposed to 0.001, 0.01, and 0.1 μg L−1 of fipronil for 24 and 96 h. Messenger RNA levels of 42 genes related to diverse metabolic pathways were analyzed by real‐time polymerase chain reaction, complemented with catalase (CAT), glutathione S‐transferase (GST), and acetylcholinesterase (AChE) activities. Few effects were observed at 24 h; however, after longer exposure (96 h), genes involved in the endocrine, detoxification, stress, and immune response pathways were altered. Moreover, fipronil at 96 h increased CAT and GST activity at 0.01 μg L−1 and AChE at the highest concentrations. The results demonstrate that even low environmentally relevant fipronil concentrations can modulate the molecular response of several cellular pathways in C. riparius after short‐term exposure. These results bring new information about the underlying response of fipronil and its mode of action on a key aquatic invertebrate. Despite no effects on mortality, strong modulation at the suborganismal level emphasizes the advantage of biomarkers as early damage responses and the harmful impact of this pesticide on freshwater organisms. Environ Toxicol Chem 2024;43:405–417. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.en
dc.description.versionversión publicada
dc.identifier.citationPinto, TDJ., Martínez-Guitarte, J.L., Amaral Dias, M., Montagner, C.C., Espindola, E.L.G., Muñiz-González, A.B. Environmentally Relevant Concentrations of the Insecticide Fipronil Modulated Molecular Response in Chironomus riparius. Environmental Toxicology and Chemistry, 43, 2, 2024, 405–417. https://doi.org/10.1002/etc.5798
dc.identifier.doihttps://doi.org/10.1002/etc.5798
dc.identifier.issn0730-7268; e-ISSN:1552-8618
dc.identifier.urihttps://hdl.handle.net/20.500.14468/24016
dc.journal.issue2
dc.journal.titleEnvironmental Toxicology and Chemistry (ET&C)
dc.journal.volume43
dc.language.isoen
dc.page.final417
dc.page.initial405
dc.publisherWiley
dc.relation.centerFacultades y escuelas::Facultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.es
dc.subject24 Ciencias de la Vida
dc.subject.keywordschironomidsen
dc.subject.keywordsinsecticidesen
dc.subject.keywordsmolecular responseen
dc.subject.keywordsreal‐time polymerase chain reaction (RT‐PCR)en
dc.subject.keywordsaquatic toxicityen
dc.subject.keywordspesticidesen
dc.titleEnvironmentally Relevant Concentrations of the Insecticide Fipronil Modulated Molecular Response in Chironomus ripariusen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationa078395f-9ae2-4e6a-b18c-2549d07bdea9
relation.isAuthorOfPublicationa060ad9d-22bf-4c0e-8f5c-4146308d7839
relation.isAuthorOfPublication.latestForDiscoverya078395f-9ae2-4e6a-b18c-2549d07bdea9
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