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Neurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Children

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dc.contributor.authorBorrego Ruiz, Alejandro
dc.contributor.authorBorrego, Juan J.
dc.date.accessioned2024-09-24T12:19:18Z
dc.date.available2024-09-24T12:19:18Z
dc.date.issued2024-06-28
dc.description.abstractThe formation of the human gut microbiome initiates in utero, and its maturation is established during the first 2–3 years of life. Numerous factors alter the composition of the gut microbiome and its functions, including mode of delivery, early onset of breastfeeding, exposure to antibiotics and chemicals, and maternal stress, among others. The gut microbiome–brain axis refers to the interconnection of biological networks that allow bidirectional communication between the gut microbiome and the brain, involving the nervous, endocrine, and immune systems. Evidence suggests that the gut microbiome and its metabolic byproducts are actively implicated in the regulation of the early brain development. Any disturbance during this stage may adversely affect brain functions, resulting in a variety of neurodevelopmental disorders (NDDs). In the present study, we reviewed recent evidence regarding the impact of the gut microbiome on early brain development, alongside its correlation with significant NDDs, such as autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome, cerebral palsy, fetal alcohol spectrum disorders, and genetic NDDs (Rett, Down, Angelman, and Turner syndromes). Understanding changes in the gut microbiome in NDDs may provide new chances for their treatment in the future.en
dc.description.versionversión publicada
dc.identifier.citationBorrego-Ruiz, A.; Borrego, J.J. Neurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Children. Children 2024, 11, 796. https://doi.org/10.3390/ children11070796
dc.identifier.doihttps://doi.org/10.3390/children11070796
dc.identifier.issn2227-9067
dc.identifier.urihttps://hdl.handle.net/20.500.14468/23818
dc.journal.titleChildren
dc.journal.volume11
dc.language.isoen
dc.publisherMDPI
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicología Social y de las Organizaciones
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject32 Ciencias Médicas ::3205 Medicina interna::3205.07 Neurología
dc.subject.keywordschildrenen
dc.subject.keywordsgut microbiomeen
dc.subject.keywordsneurodevelopmental disordersen
dc.subject.keywordsASDen
dc.subject.keywordsADHDen
dc.subject.keywordsTourette syndromeen
dc.subject.keywordscerebral palsyen
dc.subject.keywordsfetal alcohol spectrum disordersen
dc.subject.keywordsgenetic NDDsen
dc.titleNeurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Childrenes
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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