Publicación: Resolución de modelos combinados de radio y quimioterapia para el tratamiento de pequeños tumores: Células Madre Cancerígenas
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2015-09
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Universidad Nacional de Educación a Distancia (España). Facultad de Ciencias
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La carcinogénesis es un proceso complejo que aparece después de sucederse más de diez mil mutaciones genéticas, en el que se combinan factores físicos y mecánicos para su desarrollo y evolución (Koutmosakos, 2013). Esta complejidad hace necesario utilizar un enfoque multi-modelo para su correcto estudio, permitiendo no sólo analizarlo en sus etapas de crecimiento y expansión, sino también comprobar su respuesta a posibles tratamientos terapéuticos. El objetivo del modelo híbrido es comprobar el desarrollo y evolución de un tumor maligno sólido sometido a tratamientos de quimio y radioterapias, centrándose en el estudio del estado de sus células madre cancerígenas, durante y después de dichas terapias. Las células madres cancerígenas suponen sólo una pequeña porción del total de células malignas que componen un tumor, estas células tienen unas características que las hacen objetivo primordial para conseguir una erradicación completa del Cáncer (Enderling, 2009). El modelo presentado no solo demuestra que mientras existan células madre cancerígenas el tumor volverá a crecer y reproducirse, sino que al incluir un modelo de Sistema Vascular, se verifica que la posición y forma del tumor con respecto a dicho sistema será de suma importancia en el impacto producido al aplicar la radio y quimioterapia. La incorporación de un modelo de oxigenación y nutrientes permite realizar un estudio más exacto del microentorno del tumor, comprobando su respuesta celular en ambientes hipóxicos, diferenciando entre células durmientes y activas, y teniendo una distinta respuesta de dichas células a los tratamientos anteriormente mencionados (Powathil, 2012 - 2013). Los parámetros de los modelos utilizados han sido recogidos de los trabajos de Enderling (2009) y Powathil (2012, 2013)..
The carcinogenesis is a complex process that appears after happening more of ten thousand genetic mutations, in which there are combined physical and mechanical factors for his development and evolution (Koutmosakos, 2013). This complexity requires the use of a multi-shape approach for his correct study, allowing not only to analyze it in his stages of growth and expansion, but also to verify his response to possible therapeutic treatments. The aim of the hybrid model is to verify the development and evolution of a malignant solid tumor submitted to treatments of chemo and radiotherapies, focusing on the study of the state of his cancer stem cells, during and after the above mentioned therapies. The cancer stem cells suppose only a small portion of the total of malignant cells that compose a tumor, these cells possess certain peculiarities that turn them into the main focus to obtain a complete eradication of the Cancer (Enderling, 2009). The presented model does not only proves that as long as cancer stem cells exist the tumors will grow back again and will reproduce, but also verifies that by including a Vascular System Model the position and size of the tumor in such system will be extremely important on the result obtained when applying radio and chemotherapy. The incorporation of a model of oxygenation and nutrients allows to realize a more exact study of the microenvironment of the tumor, verifying his cellular response in hypoxic environments, differing between sleeping and active cells, and having a different response of the above mentioned cells to the treatments previously mentioned (Powathil, 2012 - 2013). The parameters of the used models have been gathered from the works of Enderling (2009) and Powathil (2012, 2013).
The carcinogenesis is a complex process that appears after happening more of ten thousand genetic mutations, in which there are combined physical and mechanical factors for his development and evolution (Koutmosakos, 2013). This complexity requires the use of a multi-shape approach for his correct study, allowing not only to analyze it in his stages of growth and expansion, but also to verify his response to possible therapeutic treatments. The aim of the hybrid model is to verify the development and evolution of a malignant solid tumor submitted to treatments of chemo and radiotherapies, focusing on the study of the state of his cancer stem cells, during and after the above mentioned therapies. The cancer stem cells suppose only a small portion of the total of malignant cells that compose a tumor, these cells possess certain peculiarities that turn them into the main focus to obtain a complete eradication of the Cancer (Enderling, 2009). The presented model does not only proves that as long as cancer stem cells exist the tumors will grow back again and will reproduce, but also verifies that by including a Vascular System Model the position and size of the tumor in such system will be extremely important on the result obtained when applying radio and chemotherapy. The incorporation of a model of oxygenation and nutrients allows to realize a more exact study of the microenvironment of the tumor, verifying his cellular response in hypoxic environments, differing between sleeping and active cells, and having a different response of the above mentioned cells to the treatments previously mentioned (Powathil, 2012 - 2013). The parameters of the used models have been gathered from the works of Enderling (2009) and Powathil (2012, 2013).
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Facultades y escuelas::Facultad de Ciencias
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Física Matemática y de Fluídos