Publicación:
Influence of human gut microbiome on the healthy and the neurodegenerative aging

Vista sencilla de ítem
dc.contributor.authorBorrego Ruiz, Alejandro
dc.contributor.authorBorrego, Juan J.
dc.date.accessioned2024-09-24T12:29:41Z
dc.date.available2024-09-24T12:29:41Z
dc.date.issued2024-07-27
dc.description.abstractThe gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. The microbial diversity of the human gut microbiome decreases during the aging process and, as a consequence, several mechanisms increase, such as oxidative stress, mitochondrial dysfunction, inflammatory response, and microbial gut dysbiosis. Moreover, evidence indicates that aging and neurodegeneration are closely related; consequently, the gut microbiome may serve as a novel marker of lifespan in the elderly. In this narrative study, we investigated how the changes in the composition of the gut microbiome that occur in aging influence to various neuropathological disorders, such as mild cognitive impairment (MCI), dementia, Alzheimer’s disease (AD), and Parkinson’s disease (PD); and which are the possible mechanisms that govern the relationship between the gut microbiome and cognitive impairment. In addition, several studies suggest that the gut microbiome may be a potential novel target to improve hallmarks of brain aging and to promote healthy cognition; therefore, current and future therapeutic interventions have been also reviewed.en
dc.description.versionversión publicada
dc.identifier.citationBorrego-Ruiz, A., & Borrego, J. J. (2024). Influence of human gut microbiome on the healthy and the neurodegenerative aging. Experimental Gerontology, 194, 112497. https://doi.org/10.1016/j.exger.2024.112497
dc.identifier.doihttps://doi.org/10.1016/j.exger.2024.112497
dc.identifier.issn0531-5565
dc.identifier.urihttps://hdl.handle.net/20.500.14468/23819
dc.journal.titleExperimental Gerontology
dc.journal.volume194
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicología Social y de las Organizaciones
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsAgingen
dc.subject.keywordsGut microbiomeen
dc.subject.keywordsHealthy elderlyen
dc.subject.keywordsNeurodegenerationen
dc.subject.keywordsAlzheimer’s diseaseen
dc.subject.keywordsParkinson’s diseaseen
dc.subject.keywordsMild cognitive impairmenten
dc.subject.keywordsTreatmentsen
dc.titleInfluence of human gut microbiome on the healthy and the neurodegenerative agingen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Borrego_Ruiz_Alejandro_Influence_Human_Gut.pdf
Tamaño:
2.45 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
3.62 KB
Formato:
Item-specific license agreed to upon submission
Descripción:
Descargar
Colecciones
Artículos y papers