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Pump-Free Microfluidic Device for the Electrochemical Detection of α1-Acid Glycoprotein

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dc.contributor.authorTania, Sierra
dc.contributor.authorJang, Ilhoon
dc.contributor.authorNoviana, Eka
dc.contributor.authorGonzález Crevillén, Agustín
dc.contributor.authorEscarpa, Alberto
dc.contributor.authorS. Henry, Charles
dc.date.accessioned2024-10-07T10:45:16Z
dc.date.available2024-10-07T10:45:16Z
dc.date.issued2021-07-05
dc.descriptionEste es el manuscrito aceptado del artículo. La versión registrada fue publicada por American Chemical Society Publications por primera vez en Sensors 2021 6 (8), 2998-3005, está disponible en línea en el sitio web del editor ACS Publications: https://doi.org/10.1021/acssensors.1c00864 This is the accepted manuscript of the article. The published version was first published by American Chemical Society Publications in Sensors 2021 6 (8), 2998-3005, and is available online at the publisher ACS Publications website: https://doi.org/10.1021/acssensors. 1c00864
dc.description.abstractα1-Acid glycoprotein (AGP) is a glycoprotein present in serum, which is associated with the modulation of the immune system in response to stress or injuries, and a biomarker for inflammatory diseases and cancers. Here, we propose a pump-free microfluidic device for the electrochemical determination of AGP. The microfluidic device utilizes capillary-driven flow and a passive mixing system to label the AGP with the Os (VI) complex (an electrochemical tag) inside the main channel, before delivering the products to the electrode surface. Furthermore, thanks to the resulting geometry, all the analytical steps can be carried out inside the device: labeling, washing, and detection by adsorptive transfer stripping square wave voltammetry. The microfluidic device exhibited a linear range from 500 to 2000 mg L–1 (R2 = 0.990) and adequate limit of detection (LOD = 231 mg L–1). Commercial serum samples were analyzed to demonstrate the success of the method, yielding recoveries around 83%. Due to its simplicity, low sample consumption, low cost, short analysis time, disposability, and portability, the proposed method can serve as a point-of-care/need testing device for AGP.en
dc.description.versionversión final
dc.identifier.citationTania Sierra, Ilhoon Jang, Eka Noviana, Agustín G. Crevillen, Alberto Escarpa, and Charles S. Henry ACS Sensors 2021 6 (8), 2998-3005; https://doi.org/10.1021/acssensors.1c00864
dc.identifier.doihttps://doi.org/10.1021/acssensors.1c00864
dc.identifier.issn2379-3694
dc.identifier.urihttps://hdl.handle.net/20.500.14468/23937
dc.journal.issue8
dc.journal.titleSensors
dc.journal.volume6
dc.language.isoen
dc.page.final3005
dc.page.initial2998
dc.publisherAmerican Chemical Society Publications
dc.relation.centerFacultades y escuelas::Facultad de Ciencias
dc.relation.departmentCiencias Analíticas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject23 Química
dc.subject.keywordscapillary-driven microfluidicen
dc.subject.keywordspassive mixeren
dc.subject.keywordsα1-acid glycoproteinen
dc.subject.keywordselectrochemical detectionen
dc.subject.keywordselectrochemical tagen
dc.titlePump-Free Microfluidic Device for the Electrochemical Detection of α1-Acid Glycoproteinen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
person.familyNameGonzález Crevillén
person.givenNameAgustín
person.identifier.orcid0000-0002-4470-6502
relation.isAuthorOfPublication0f39284a-d95a-443a-bb2e-21297ec40b76
relation.isAuthorOfPublication.latestForDiscovery0f39284a-d95a-443a-bb2e-21297ec40b76
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