Publicación:
Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats

Vista sencilla de ítem
dc.contributor.authorNazarian, Arbi
dc.contributor.authorIbias Martín, Javier
dc.date.accessioned2024-05-20T11:50:43Z
dc.date.available2024-05-20T11:50:43Z
dc.date.issued2020-12
dc.description.abstractAbstract References Supplementary Material Get access Cite article Share options Information, rights and permissions Metrics and citations Abstract Background: Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance-use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. Aims and methods: In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. Results: When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behaviour, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as they showed results close to their baseline levels. On the other hand, bupropion did not affect the nicotine-induced delay discounting in male rats. Conclusion: These findings demonstrate sexually dimorphic effects of nicotine on cognitive impulsivity which may help to shed light on nicotine use vulnerabilities observed in women.en
dc.description.versionversión final
dc.identifier.doihttp://doi.org/10.1177/0269881120937543
dc.identifier.issn1461-7285
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12625
dc.journal.issue12
dc.journal.titleJournal of Psychopharmacology
dc.journal.volume34
dc.language.isoen
dc.publisherSAGE
dc.relation.centerFacultad de Psicología
dc.relation.departmentMetodología de las Ciencias del Comportamiento
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsNicotine
dc.subject.keywordsdelay discounting
dc.subject.keywordsimpulsivity
dc.subject.keywordssex differences
dc.subject.keywordsbupropion
dc.titleSex differences in nicotine-induced impulsivity and its reversal with bupropion in ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication309c25b3-8ac4-4106-9ad3-4a441098fae9
relation.isAuthorOfPublication.latestForDiscovery309c25b3-8ac4-4106-9ad3-4a441098fae9
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
IBIAS_MARTIN_JAVIER_Sex_differences.pdf
Tamaño:
986.11 KB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos y papers