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Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats

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dc.contributor.authorKojo Morgan, Godstime Stephen
dc.contributor.authorMata, Yolanda
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorPellón Suárez de Puga, Ricardo
dc.contributor.authorCollado Guirao, Paloma
dc.contributor.authorGotti, Stefano
dc.contributor.authorPinos Sánchez, María Elena
dc.date.accessioned2025-01-08T12:18:43Z
dc.date.available2025-01-08T12:18:43Z
dc.date.issued2022-11
dc.descriptionhttps://doi.org/10.1016/j.neures.2022.08.001
dc.description.abstractA principal animal paradigm employed in Anorexia Nervosa (AN) study is the activity-based anorexia (ABA) model. The model's efficacy in recapitulating the core features of AN in humans allows for the study of the parameters involved in the disorder. The current study examined the susceptibility to the ABA protocol in the presence of a significant stressor (maternal separation) in male and female Sprague Dawley rats. More importantly, we analysed the sex-differences on activity levels during different periods of the ABA protocol to determine the period(s) influencing the most pathological weight loss. Both components of the ABA protocol contributed to the subjects’ bodyweight loss. Stress in the first two weeks of development conferred a protective effect in males. Time spent and activity levels on the running wheel were higher in females compared to males. Hyperactivity in ABA subjects was observed during the food-anticipatory activity (FAA) and postprandial activity in males and during the FAA and nocturnal activity periods in females. This study aids in understanding the effect of intensity of activity during specific periods on the pathological weight loss in ABA rats. These observations are informative for therapies aimed at ameliorating body mass index in AN patients.en
dc.description.versionversión final
dc.identifier.citationMorgan GSK., Mata Y., Carrillo B., Pellón R., Collado P., Gotti S., Pinos H. (2022) Influence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley rats. Neurosci. Res., 184, 54-61.
dc.identifier.doihttps://doi.org/10.1016/j.neures.2022.08.001
dc.identifier.issn0168-0102
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25128
dc.journal.titleNeuroscience Research
dc.journal.volume184
dc.language.isoes
dc.page.final61
dc.page.initial54
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsMaternal separationen
dc.subject.keywordsanorexia nervosaen
dc.subject.keywordsactivity-based anorexiaen
dc.subject.keywordsfood anticipatory activityen
dc.subject.keywordssex differencesen
dc.titleInfluence of early maternal separation on susceptibility to the activity-based anorexia model in male and female Sprague Dawley ratsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublication8edbde84-9307-47aa-9ef8-5e85de175df6
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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