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Chronic ∆-9-Tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

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dc.contributor.authorFuentes Verdugo, Esmeralda
dc.contributor.authorLópez Tolsa Gómez, Gabriela Eugenia
dc.contributor.authorPellón Suárez de Puga, Ricardo
dc.contributor.authorMiguens Vázquez, Miguel
dc.date.accessioned2024-10-14T08:47:28Z
dc.date.available2024-10-14T08:47:28Z
dc.date.issued2021-08-26
dc.description.abstractRationale: Schedule-induced drinking (SID) is a behavioural phenomenon characterized by an excessive and repetitive drinking pattern with a distinctive temporal distribution that has been proposed as a robust and replicable animal model of compulsivity. Despite cannabis currently being the most widely consumed illicit drug, with growing interest in its clinical applications, little is known about the effects of ∆-9-Tetrahydrocannabinol (THC) on SID. Objectives: The effects of chronic and acute THC administration on SID acquisition, maintenance and extinction were studied, as were the effects of such administrations on the distinctive temporal distribution pattern of SID. Methods: THC (5 mg/kg i.p.), or the corresponding vehicle, was administered to adult Wistar rats for 14 days in a row. Subsequently, THC effects on SID acquisition were tested during 21 sessions using a 1h fixed-time 60-s food delivery schedule. Acute effects of THC were also evaluated after SID development. Finally, two extinction sessions were conducted to assess behavioural persistence. Results: The results showed that previous chronic THC treatment delayed SID acquisition and altered the distinctive behavioural temporal distribution pattern during sessions. Moreover, acute THC administration after SID development decreased SID performance in animals chronically pre-treated with the drug. No great persistence effects were observed during extinction in animals pre-treated with THC. Conclusions: These results suggest that chronic THC affects SID development, confirming that it can disrupt learning, possibly causing alterations in time estimation, and also leads to animals being sensitized when they are re-exposed to the drug after long periods without drug exposure.en
dc.description.versionversión final
dc.identifier.citationFuentes-Verdugo, E., López-Tolsa, G.E., Pellón, R. et al. Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects. Psychopharmacology 239, 1359–1372 (2022). https://doi.org/10.1007/s00213-021-05952-2
dc.identifier.doihttps://doi.org/10.1007/s00213-021-05952-2
dc.identifier.issn0033-3158; e-ISSN : 1432-2072
dc.identifier.urihttps://hdl.handle.net/20.500.14468/24039
dc.journal.titlePsychopharmacology
dc.journal.volume239
dc.language.isoen
dc.page.final1372
dc.page.initial1359
dc.publisherSpringer
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicología Básica I
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsTHCen
dc.subject.keywordscannabisen
dc.subject.keywordsadjunctive behaviouren
dc.subject.keywordssensitizationen
dc.subject.keywordstime estimationen
dc.titleChronic ∆-9-Tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effectsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublication8edbde84-9307-47aa-9ef8-5e85de175df6
relation.isAuthorOfPublication5329dfae-47ff-4e74-8de7-9daab9d7a92c
relation.isAuthorOfPublication.latestForDiscoveryba8ed850-8d02-456c-8d85-9290e6c6bab9
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