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Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes

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dc.contributor.authorO’Dell, Laura E.
dc.contributor.authorNazarian, Arbi
dc.contributor.authorIbias Martín, Javier
dc.date.accessioned2024-05-20T11:50:34Z
dc.date.available2024-05-20T11:50:34Z
dc.date.issued2018-10-01
dc.description.abstractThe rewarding effects of nicotine have been previously shown to be enhanced in rodent models of diabetes. It is presently unclear whether the enhanced nicotine reward observed in the diabetes models are mediated via an insulin or glucose mechanism. This study examined whether the enhanced rewarding effects of nicotine observed in streptozotocin (STZ)-treated rats are insulin-mediated. Male and female rats were treated with STZ and the rewarding effects of nicotine (0.2 mg/kg) were measured using the conditioned place preference (CPP) procedure. Some STZ-treated animals received insulin supplementation via subcutaneous pellets immediately after STZ administration, while other rats received daily injections of dapagliflozin (10 mg/kg), a sodium-glucose cotransporter-2 inhibitor. Both male and female STZ-treated rats displayed hyperglycemia, and their blood glucose levels (BGLs) were normalized to control levels following insulin supplementation or dapagliflozin administration. STZ-treated male rats displayed higher nicotine CPP relative to vehicle-treated controls. This effect was abolished in rats that received insulin supplementation or dapagliflozin administration. STZ-treated female rats displayed reduced levels of nicotine CPP as compared to male rats, regardless of treatment condition. These results suggest that glucose plays a major role in modulating the rewarding effects of nicotine in male rats treated with STZ.en
dc.description.versionversión original
dc.identifier.doihttp://doi.org/10.1016/j.bbr.2018.05.018
dc.identifier.issn0166-4328
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12622
dc.journal.titleBehavioural Brain Research
dc.journal.volume351
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentMetodología de las Ciencias del Comportamiento
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsStreptozotocin
dc.subject.keywordsInsulin
dc.subject.keywordsDapagliflozin
dc.subject.keywordsHyperglycemia
dc.subject.keywordsDiabetes
dc.subject.keywordsPlace preference
dc.titleInsulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabeteses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication309c25b3-8ac4-4106-9ad3-4a441098fae9
relation.isAuthorOfPublication.latestForDiscovery309c25b3-8ac4-4106-9ad3-4a441098fae9
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